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Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection.
J Clin Microbiol. 1975 Sep; 2(3):193-7.JC

Abstract

Levels of lymphocytic choriomeningitis virus antibody were assayed in 62 infected persons. The three tests used were indirect fluorescent antibody (IFA), complement fixation, and neutralization in mice. The sera first became positive by the IFA test, and IFA titers rapidly rose to a relatively high level, with the sera remaining positive long after the antibody detectable by complement fixation had disappeared. The IFA test appeared to be specific. The sera became positive last by the mouse neutralization test; with this test, antibody first appeared several weeks after infection. Virus-infected cells were stable when stored at -60 C, allowing diagnostic sera to be tested promptly by the IFA test. The IFA test for lymphocytic choriomeningitis antibody should increase the number of serological diagnoses, since it is not only rapid and specific, but detects cases not diagnosed by the other methods.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1100673

Citation

Lewis, V J., et al. "Comparison of Three Tests for the Serological Diagnosis of Lymphocytic Choriomeningitis Virus Infection." Journal of Clinical Microbiology, vol. 2, no. 3, 1975, pp. 193-7.
Lewis VJ, Walter PD, Thacker WL, et al. Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection. J Clin Microbiol. 1975;2(3):193-7.
Lewis, V. J., Walter, P. D., Thacker, W. L., & Winkler, W. G. (1975). Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection. Journal of Clinical Microbiology, 2(3), 193-7.
Lewis VJ, et al. Comparison of Three Tests for the Serological Diagnosis of Lymphocytic Choriomeningitis Virus Infection. J Clin Microbiol. 1975;2(3):193-7. PubMed PMID: 1100673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection. AU - Lewis,V J, AU - Walter,P D, AU - Thacker,W L, AU - Winkler,W G, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 193 EP - 7 JF - Journal of clinical microbiology JO - J. Clin. Microbiol. VL - 2 IS - 3 N2 - Levels of lymphocytic choriomeningitis virus antibody were assayed in 62 infected persons. The three tests used were indirect fluorescent antibody (IFA), complement fixation, and neutralization in mice. The sera first became positive by the IFA test, and IFA titers rapidly rose to a relatively high level, with the sera remaining positive long after the antibody detectable by complement fixation had disappeared. The IFA test appeared to be specific. The sera became positive last by the mouse neutralization test; with this test, antibody first appeared several weeks after infection. Virus-infected cells were stable when stored at -60 C, allowing diagnostic sera to be tested promptly by the IFA test. The IFA test for lymphocytic choriomeningitis antibody should increase the number of serological diagnoses, since it is not only rapid and specific, but detects cases not diagnosed by the other methods. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/1100673/Comparison_of_three_tests_for_the_serological_diagnosis_of_lymphocytic_choriomeningitis_virus_infection_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=1100673 DB - PRIME DP - Unbound Medicine ER -