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CagA-positive strains of Helicobacter pylori may protect against Barrett's esophagus.
Am J Gastroenterol 2000; 95(9):2206-11AJ

Abstract

OBJECTIVE

Helicobacter pylori (H. pylori) colonization is associated with chronic gastritis, peptic ulcer disease, and adenocarcinoma of the distal stomach. However, the role of H. pylori strain variation in complicated gastroesophageal reflux disease, especially Barrett's esophagus, is unknown. Therefore, the aim of this study was to evaluate the prevalence of colonization by cagA+ and cagA- H. pylori strains in the spectrum of gastroesophageal reflux disease, including Barrett's esophagus.

METHODS

A total of 251 patients undergoing endoscopy were categorized into four groups: controls, patients with gastroesophageal reflux disease alone, and patients with short- and long-segment Barrett's esophagus. All patients underwent upper endoscopies with biopsies and serum collections. H. pylori and degree of mucosal inflammation in gastric biopsies were assessed and serological assessment made for H. pylori and cagA status.

RESULTS

The overall prevalence of H. pylori colonization in the study population was 35% (95% confidence interval = 29.5-41.4%) which did not differ significantly among the groups. However, colonization by cagA+ H. pylori strains was significantly more prevalent among controls (11/25; 44%) and patients with gastroesophageal reflux disease (13/36; 36%) than in patients with short-segment (2/10; 20%) or long-segment Barrett's esophagus (0/18; 0%). Patients with Barrett's esophagus were less likely to be colonized by cagA+ H. pylori strains than reflux patients without Barrett's esophagus (odds ratio = 0.27, 95% confidence interval = 0.11-0.67, p = 0.004).

CONCLUSIONS

Colonization by cagA+ H. pylori strains may be protective against the formation of short- and long-segment Barrett's esophagus and its malignant complications.

Authors+Show Affiliations

Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11007219

Citation

Vaezi, M F., et al. "CagA-positive Strains of Helicobacter Pylori May Protect Against Barrett's Esophagus." The American Journal of Gastroenterology, vol. 95, no. 9, 2000, pp. 2206-11.
Vaezi MF, Falk GW, Peek RM, et al. CagA-positive strains of Helicobacter pylori may protect against Barrett's esophagus. Am J Gastroenterol. 2000;95(9):2206-11.
Vaezi, M. F., Falk, G. W., Peek, R. M., Vicari, J. J., Goldblum, J. R., Perez-Perez, G. I., ... Richter, J. E. (2000). CagA-positive strains of Helicobacter pylori may protect against Barrett's esophagus. The American Journal of Gastroenterology, 95(9), pp. 2206-11.
Vaezi MF, et al. CagA-positive Strains of Helicobacter Pylori May Protect Against Barrett's Esophagus. Am J Gastroenterol. 2000;95(9):2206-11. PubMed PMID: 11007219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CagA-positive strains of Helicobacter pylori may protect against Barrett's esophagus. AU - Vaezi,M F, AU - Falk,G W, AU - Peek,R M, AU - Vicari,J J, AU - Goldblum,J R, AU - Perez-Perez,G I, AU - Rice,T W, AU - Blaser,M J, AU - Richter,J E, PY - 2000/9/28/pubmed PY - 2000/10/14/medline PY - 2000/9/28/entrez SP - 2206 EP - 11 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 95 IS - 9 N2 - OBJECTIVE: Helicobacter pylori (H. pylori) colonization is associated with chronic gastritis, peptic ulcer disease, and adenocarcinoma of the distal stomach. However, the role of H. pylori strain variation in complicated gastroesophageal reflux disease, especially Barrett's esophagus, is unknown. Therefore, the aim of this study was to evaluate the prevalence of colonization by cagA+ and cagA- H. pylori strains in the spectrum of gastroesophageal reflux disease, including Barrett's esophagus. METHODS: A total of 251 patients undergoing endoscopy were categorized into four groups: controls, patients with gastroesophageal reflux disease alone, and patients with short- and long-segment Barrett's esophagus. All patients underwent upper endoscopies with biopsies and serum collections. H. pylori and degree of mucosal inflammation in gastric biopsies were assessed and serological assessment made for H. pylori and cagA status. RESULTS: The overall prevalence of H. pylori colonization in the study population was 35% (95% confidence interval = 29.5-41.4%) which did not differ significantly among the groups. However, colonization by cagA+ H. pylori strains was significantly more prevalent among controls (11/25; 44%) and patients with gastroesophageal reflux disease (13/36; 36%) than in patients with short-segment (2/10; 20%) or long-segment Barrett's esophagus (0/18; 0%). Patients with Barrett's esophagus were less likely to be colonized by cagA+ H. pylori strains than reflux patients without Barrett's esophagus (odds ratio = 0.27, 95% confidence interval = 0.11-0.67, p = 0.004). CONCLUSIONS: Colonization by cagA+ H. pylori strains may be protective against the formation of short- and long-segment Barrett's esophagus and its malignant complications. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11007219/CagA_positive_strains_of_Helicobacter_pylori_may_protect_against_Barrett's_esophagus_ L2 - http://Insights.ovid.com/pubmed?pmid=11007219 DB - PRIME DP - Unbound Medicine ER -