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Indication for epidural morphine for the relief of intractable pain in advanced oral cancer: report of four cases.
Br J Oral Maxillofac Surg. 2000 Oct; 38(5):546-9.BJ

Abstract

It can be difficult to manage the pain of advanced oral cancer. We present four patients in whom epidural morphine was used for intractable pain at primary or metastatic sites. For pain supplied by the trigeminal or cervical nerve a small dose of morphine was given through an epidural catheter inserted into the epidural space through C7-Th1. A favourable clinical response was achieved in three. In particular, in one patient who was given continuous morphine using a computerized ambulatory drug delivery system, we achieved excellent efficacy and stable control of pain. We think that the effect of the epidural morphine was decreased in the patient who did not respond because he had previously been treated with high oral doses. The present study confirmed that morphine given epidurally in small doses has a strong and prolonged analgesic action with less toxicity than when given orally.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Journal Article
Review

Language

eng

PubMed ID

11010793

Citation

Kayahara, H, et al. "Indication for Epidural Morphine for the Relief of Intractable Pain in Advanced Oral Cancer: Report of Four Cases." The British Journal of Oral & Maxillofacial Surgery, vol. 38, no. 5, 2000, pp. 546-9.
Kayahara H, Hamakawa H, Fukuzumi M, et al. Indication for epidural morphine for the relief of intractable pain in advanced oral cancer: report of four cases. Br J Oral Maxillofac Surg. 2000;38(5):546-9.
Kayahara, H., Hamakawa, H., Fukuzumi, M., & Tanioka, H. (2000). Indication for epidural morphine for the relief of intractable pain in advanced oral cancer: report of four cases. The British Journal of Oral & Maxillofacial Surgery, 38(5), 546-9.
Kayahara H, et al. Indication for Epidural Morphine for the Relief of Intractable Pain in Advanced Oral Cancer: Report of Four Cases. Br J Oral Maxillofac Surg. 2000;38(5):546-9. PubMed PMID: 11010793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indication for epidural morphine for the relief of intractable pain in advanced oral cancer: report of four cases. AU - Kayahara,H, AU - Hamakawa,H, AU - Fukuzumi,M, AU - Tanioka,H, PY - 2000/9/30/pubmed PY - 2001/3/3/medline PY - 2000/9/30/entrez SP - 546 EP - 9 JF - The British journal of oral & maxillofacial surgery JO - Br J Oral Maxillofac Surg VL - 38 IS - 5 N2 - It can be difficult to manage the pain of advanced oral cancer. We present four patients in whom epidural morphine was used for intractable pain at primary or metastatic sites. For pain supplied by the trigeminal or cervical nerve a small dose of morphine was given through an epidural catheter inserted into the epidural space through C7-Th1. A favourable clinical response was achieved in three. In particular, in one patient who was given continuous morphine using a computerized ambulatory drug delivery system, we achieved excellent efficacy and stable control of pain. We think that the effect of the epidural morphine was decreased in the patient who did not respond because he had previously been treated with high oral doses. The present study confirmed that morphine given epidurally in small doses has a strong and prolonged analgesic action with less toxicity than when given orally. SN - 0266-4356 UR - https://www.unboundmedicine.com/medline/citation/11010793/Indication_for_epidural_morphine_for_the_relief_of_intractable_pain_in_advanced_oral_cancer:_report_of_four_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0266-4356(00)90476-5 DB - PRIME DP - Unbound Medicine ER -