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Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen.
Aliment Pharmacol Ther 2000; 14(10):1329-34AP

Abstract

BACKGROUND

The most widely used treatments for ulcer healing and Helicobacter pylori eradication consist of a 1-2 week regimen of a proton pump inhibitor plus two or three antimicrobials.

AIMS

To evaluate the efficacy, safety, cost, and tolerance of a three-day regimen with three antibiotics vs. a 10-day treatment with a proton pump inhibitor or vs. a ranitidine bismuth citrate triple therapy.

METHODS

Two hundred and twenty-one patients with endoscopically-proven H. pylori-positive duodenal ulcers were recruited to the study. Recruited patients were assigned to one of the following four regimens: (I) omeprazole 40 mg o.m. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (OAC: 55 patients); (ii) omeprazole 40 mg o.m. on days 1-5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3-5 (OACM: 56 patients); (iii) ranitidine bismuth citrate 400 mg b.d. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (RAC: 54 patients); (iv) ranitidine bismuth citrate 400 mg b.d. on days 1-5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3-5 (RACM: 56 patients). Fisher's exact test was used to compare data regarding healing and eradication in the four groups.

RESULTS

The intention-to-treat eradication and ulcer healing rates for the RACM regimen were 95% and 98%, respectively. Statistically significant differences were observed, relating to the eradication and healing of ulcers, between RACM and either the RAC or OAC regimens.

CONCLUSION

The three-day antibiotic therapy with amoxycillin, clarithromycin and metronidazole in addition to ranitidine bismuth citrate is a very effective anti-H. pylori regimen.

Authors+Show Affiliations

Gastroenterology and Digestive Endoscopy Service, University of Catania, Italy. F.Catalano@mbox.unict.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11012478

Citation

Catalano, F, et al. "Helicobacter Pylori-positive Duodenal Ulcer: Three-day Antibiotic Eradication Regimen." Alimentary Pharmacology & Therapeutics, vol. 14, no. 10, 2000, pp. 1329-34.
Catalano F, Branciforte G, Catanzaro R, et al. Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen. Aliment Pharmacol Ther. 2000;14(10):1329-34.
Catalano, F., Branciforte, G., Catanzaro, R., Cipolla, R., Bentivegna, C., & Brogna, A. (2000). Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen. Alimentary Pharmacology & Therapeutics, 14(10), pp. 1329-34.
Catalano F, et al. Helicobacter Pylori-positive Duodenal Ulcer: Three-day Antibiotic Eradication Regimen. Aliment Pharmacol Ther. 2000;14(10):1329-34. PubMed PMID: 11012478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen. AU - Catalano,F, AU - Branciforte,G, AU - Catanzaro,R, AU - Cipolla,R, AU - Bentivegna,C, AU - Brogna,A, PY - 2000/9/30/pubmed PY - 2001/2/28/medline PY - 2000/9/30/entrez SP - 1329 EP - 34 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 14 IS - 10 N2 - BACKGROUND: The most widely used treatments for ulcer healing and Helicobacter pylori eradication consist of a 1-2 week regimen of a proton pump inhibitor plus two or three antimicrobials. AIMS: To evaluate the efficacy, safety, cost, and tolerance of a three-day regimen with three antibiotics vs. a 10-day treatment with a proton pump inhibitor or vs. a ranitidine bismuth citrate triple therapy. METHODS: Two hundred and twenty-one patients with endoscopically-proven H. pylori-positive duodenal ulcers were recruited to the study. Recruited patients were assigned to one of the following four regimens: (I) omeprazole 40 mg o.m. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (OAC: 55 patients); (ii) omeprazole 40 mg o.m. on days 1-5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3-5 (OACM: 56 patients); (iii) ranitidine bismuth citrate 400 mg b.d. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (RAC: 54 patients); (iv) ranitidine bismuth citrate 400 mg b.d. on days 1-5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3-5 (RACM: 56 patients). Fisher's exact test was used to compare data regarding healing and eradication in the four groups. RESULTS: The intention-to-treat eradication and ulcer healing rates for the RACM regimen were 95% and 98%, respectively. Statistically significant differences were observed, relating to the eradication and healing of ulcers, between RACM and either the RAC or OAC regimens. CONCLUSION: The three-day antibiotic therapy with amoxycillin, clarithromycin and metronidazole in addition to ranitidine bismuth citrate is a very effective anti-H. pylori regimen. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/11012478/Helicobacter_pylori_positive_duodenal_ulcer:_three_day_antibiotic_eradication_regimen_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2000&volume=14&issue=10&spage=1329 DB - PRIME DP - Unbound Medicine ER -