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Gastric secretory response to graded doses of pentagastrin alone or in combination with carbacholine in unoperated duodenal ulcer patients.
Scand J Gastroenterol. 1975; 10(6):603-8.SJ

Abstract

Dose-response studies of pentagastrin-stimulated secretion were performed in 6 unoperated duodenal ulcer patients. On different days pentagastrin was given in doses of 0.15, 1.5, and 15 mug/kg/hr, either alone or in combination with carbacholine, 2 mug/kg/hr. There were no significant differences between mean acid or pepsin outputs or mean volumes of gastric juice after infusion of pentagastrin alone or pentagastrin plus carbacholine at any dose step of pentagastrin. The dose of pentagastrin required to elicit half maximal acid output (Km) and the calculated maximal acid output (Vmax) were the same for pentagastrin alone and pentgastrin plus carbacholine. Thus, carbacholine did not increase the sensitivity of the parietal cells to pentagastrin in the unoperated duodenal ulcer patients.

Authors

Roland M
No affiliation info available

MeSH

AdultAgedCarbacholDose-Response Relationship, DrugDuodenal UlcerGastric JuiceGastric MucosaHumansInjections, IntravenousMiddle AgedPentagastrinPepsin ASecretory RateStimulation, Chemical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1101365

Citation

Roland, M. "Gastric Secretory Response to Graded Doses of Pentagastrin Alone or in Combination With Carbacholine in Unoperated Duodenal Ulcer Patients." Scandinavian Journal of Gastroenterology, vol. 10, no. 6, 1975, pp. 603-8.
Roland M. Gastric secretory response to graded doses of pentagastrin alone or in combination with carbacholine in unoperated duodenal ulcer patients. Scand J Gastroenterol. 1975;10(6):603-8.
Roland, M. (1975). Gastric secretory response to graded doses of pentagastrin alone or in combination with carbacholine in unoperated duodenal ulcer patients. Scandinavian Journal of Gastroenterology, 10(6), 603-8.
Roland M. Gastric Secretory Response to Graded Doses of Pentagastrin Alone or in Combination With Carbacholine in Unoperated Duodenal Ulcer Patients. Scand J Gastroenterol. 1975;10(6):603-8. PubMed PMID: 1101365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric secretory response to graded doses of pentagastrin alone or in combination with carbacholine in unoperated duodenal ulcer patients. A1 - Roland,M, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 603 EP - 8 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 10 IS - 6 N2 - Dose-response studies of pentagastrin-stimulated secretion were performed in 6 unoperated duodenal ulcer patients. On different days pentagastrin was given in doses of 0.15, 1.5, and 15 mug/kg/hr, either alone or in combination with carbacholine, 2 mug/kg/hr. There were no significant differences between mean acid or pepsin outputs or mean volumes of gastric juice after infusion of pentagastrin alone or pentagastrin plus carbacholine at any dose step of pentagastrin. The dose of pentagastrin required to elicit half maximal acid output (Km) and the calculated maximal acid output (Vmax) were the same for pentagastrin alone and pentgastrin plus carbacholine. Thus, carbacholine did not increase the sensitivity of the parietal cells to pentagastrin in the unoperated duodenal ulcer patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/1101365/Gastric_secretory_response_to_graded_doses_of_pentagastrin_alone_or_in_combination_with_carbacholine_in_unoperated_duodenal_ulcer_patients_ DB - PRIME DP - Unbound Medicine ER -