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Effect of subclinical hypothyroidism on body fluid compartments.
Horm Metab Res. 2000 Sep; 32(9):359-63.HM

Abstract

OBJECTIVE

The present study was aimed to assess the effects of subclinical hypothyroidism on body composition (BC).

SUBJECTS

Thirty-one women (age: 37 +/- 9.9 years) with a wide range of body mass index (BMI) were studied. Subclinical hypothyroidism was defined by a basal TSH > or = 4 mU/L and/or TRH stimulated peak > or = 30 mU/L.

MEASUREMENTS

For each subject, weight, height, BMI, multifrequency bioelectrical impedance spectroscopy (BIS) and D2O and NaBr dilution tests were performed to assessed total body water (TBW) and extracellular water (ECW). Thyroid function (basal and TRH stimulated TSH, free T3, and free T4) were determined from fasting blood samples for all subjects. Total body dual energy X-ray absorptiometry (DXA) were used to measure fat mass (FM) and lean mass (Lean).

RESULTS

The results of BIS were compared with the TBW and ECW estimated by the dilution techniques on the same individuals. The correlation was R2 = 0.65 for impedance at 5 kHz and ECW by NaBr and R2 = 0.72 for impedance at 100 kHz and TBW by D2O. Intracellular water (ICW) was calculated as differences between TBW and ECW measured by dilution methods. Percent of ECW and ICW were related to BMI (ANOVA, p < 0.001). No difference in TBW, body water distribution and body composition related to thyroid function was demonstrated.

CONCLUSIONS

In our patients affected with subclinical hypothyroidism, with or without obesity, only obesity appeared related to TBW, ECW and ICW; the subclinical hypothyroidism, on the contrary, had no effect on compartments of body fluids. Bioimpedance is a valid tool to assess body fluid distribution in subclinical hypothyroidism.

Authors+Show Affiliations

Human Nutrition Unit, University of Rome Tor Vergata, Italy. DELORENZO@UNIROMA2.ITNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11014384

Citation

De Lorenzo, A, et al. "Effect of Subclinical Hypothyroidism On Body Fluid Compartments." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 32, no. 9, 2000, pp. 359-63.
De Lorenzo A, Andreoli A, Fusco A, et al. Effect of subclinical hypothyroidism on body fluid compartments. Horm Metab Res. 2000;32(9):359-63.
De Lorenzo, A., Andreoli, A., Fusco, A., Magnani, A., D'Orazio, N., & Bertoli, A. (2000). Effect of subclinical hypothyroidism on body fluid compartments. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 32(9), 359-63.
De Lorenzo A, et al. Effect of Subclinical Hypothyroidism On Body Fluid Compartments. Horm Metab Res. 2000;32(9):359-63. PubMed PMID: 11014384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of subclinical hypothyroidism on body fluid compartments. AU - De Lorenzo,A, AU - Andreoli,A, AU - Fusco,A, AU - Magnani,A, AU - D'Orazio,N, AU - Bertoli,A, PY - 2000/10/3/pubmed PY - 2001/2/28/medline PY - 2000/10/3/entrez SP - 359 EP - 63 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 32 IS - 9 N2 - OBJECTIVE: The present study was aimed to assess the effects of subclinical hypothyroidism on body composition (BC). SUBJECTS: Thirty-one women (age: 37 +/- 9.9 years) with a wide range of body mass index (BMI) were studied. Subclinical hypothyroidism was defined by a basal TSH > or = 4 mU/L and/or TRH stimulated peak > or = 30 mU/L. MEASUREMENTS: For each subject, weight, height, BMI, multifrequency bioelectrical impedance spectroscopy (BIS) and D2O and NaBr dilution tests were performed to assessed total body water (TBW) and extracellular water (ECW). Thyroid function (basal and TRH stimulated TSH, free T3, and free T4) were determined from fasting blood samples for all subjects. Total body dual energy X-ray absorptiometry (DXA) were used to measure fat mass (FM) and lean mass (Lean). RESULTS: The results of BIS were compared with the TBW and ECW estimated by the dilution techniques on the same individuals. The correlation was R2 = 0.65 for impedance at 5 kHz and ECW by NaBr and R2 = 0.72 for impedance at 100 kHz and TBW by D2O. Intracellular water (ICW) was calculated as differences between TBW and ECW measured by dilution methods. Percent of ECW and ICW were related to BMI (ANOVA, p < 0.001). No difference in TBW, body water distribution and body composition related to thyroid function was demonstrated. CONCLUSIONS: In our patients affected with subclinical hypothyroidism, with or without obesity, only obesity appeared related to TBW, ECW and ICW; the subclinical hypothyroidism, on the contrary, had no effect on compartments of body fluids. Bioimpedance is a valid tool to assess body fluid distribution in subclinical hypothyroidism. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/11014384/Effect_of_subclinical_hypothyroidism_on_body_fluid_compartments_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-978653 DB - PRIME DP - Unbound Medicine ER -