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Molecular aspects of avian influenza (H5N1) viruses isolated from humans.
Rev Med Virol 2000 Sep-Oct; 10(5):337-48RM

Abstract

In 1997, 18 human infections with H5N1 influenza type A were identified in Hong Kong and six of the patients died. There were concomitant outbreaks of H5N1 infections in poultry. The gene segments of the human H5N1 viruses were derived from avian influenza A viruses and not from circulating human influenza A viruses. In 1999 two cases of human infections caused by avian H9N2 virus were also identified in Hong Kong. These events established that avian influenza viruses can infect humans without passage through an intermediate host and without acquiring gene segments from human influenza viruses. The likely origin of the H5N1 viruses has been deduced from molecular analysis of these and other viruses isolated from the region. The gene sequences of the H5N1 viruses were analysed in order to identify the molecular basis for the ability of these avian viruses to infect humans.

Authors+Show Affiliations

Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11015744

Citation

Subbarao, K, and M W. Shaw. "Molecular Aspects of Avian Influenza (H5N1) Viruses Isolated From Humans." Reviews in Medical Virology, vol. 10, no. 5, 2000, pp. 337-48.
Subbarao K, Shaw MW. Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev Med Virol. 2000;10(5):337-48.
Subbarao, K., & Shaw, M. W. (2000). Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Reviews in Medical Virology, 10(5), pp. 337-48.
Subbarao K, Shaw MW. Molecular Aspects of Avian Influenza (H5N1) Viruses Isolated From Humans. Rev Med Virol. 2000;10(5):337-48. PubMed PMID: 11015744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular aspects of avian influenza (H5N1) viruses isolated from humans. AU - Subbarao,K, AU - Shaw,M W, PY - 2000/10/4/pubmed PY - 2001/2/28/medline PY - 2000/10/4/entrez SP - 337 EP - 48 JF - Reviews in medical virology JO - Rev. Med. Virol. VL - 10 IS - 5 N2 - In 1997, 18 human infections with H5N1 influenza type A were identified in Hong Kong and six of the patients died. There were concomitant outbreaks of H5N1 infections in poultry. The gene segments of the human H5N1 viruses were derived from avian influenza A viruses and not from circulating human influenza A viruses. In 1999 two cases of human infections caused by avian H9N2 virus were also identified in Hong Kong. These events established that avian influenza viruses can infect humans without passage through an intermediate host and without acquiring gene segments from human influenza viruses. The likely origin of the H5N1 viruses has been deduced from molecular analysis of these and other viruses isolated from the region. The gene sequences of the H5N1 viruses were analysed in order to identify the molecular basis for the ability of these avian viruses to infect humans. SN - 1052-9276 UR - https://www.unboundmedicine.com/medline/citation/11015744/Molecular_aspects_of_avian_influenza__H5N1__viruses_isolated_from_humans_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -