Tags

Type your tag names separated by a space and hit enter

Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes.
Clin Cardiol. 2000 Sep; 23(9):655-8.CC

Abstract

BACKGROUND

Oxidized lipoproteins may play an important role in the pathogenesis of atherosclerosis, and it has been shown that antioxidants have a protective effect against the progression of atherosclerosis.

HYPOTHESIS

The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris.

METHODS

The study population included 70 patients with acute coronary syndromes (14 with recent acute myocardial infarction and 56 with unstable angina pectoris), 105 patients with stable angina pectoris, and 75 control subjects. In addition to conventional lipid and lipoprotein analysis, the susceptibility of apolipoprotein B-containing lipoproteins to in vitro oxidation (lag phase) and plasma vitamin E and total carotene levels was measured.

RESULTS

The lag phase was significantly shorter in patients with acute coronary syndromes (45 +/- 12 min) than in patients with stable angina pectoris (51 +/- 10 min) and in control subjects (58 +/- 9 min) (p < 0.0001). Both plasma vitamin E and total carotene levels were lowest in patients with acute coronary syndromes (1.11 +/- 0.32 mg/dl and 119 +/- 32 micrograms/dl, respectively), followed by patients with stable angina pectoris (1.25 +/- 0.37 mg/dl and 132 +/- 37 micrograms/dl) and then controls (1.52 +/- 0.31 mg/dl and 167 +/- 41 micrograms/dl).

CONCLUSIONS

These data suggest that there is an intense oxidative process and a lower antioxidant status in acute coronary syndromes. This may lead to plaque instability due to the activation of the inflammatory response in coronary atherosclerotic lesions.

Authors+Show Affiliations

Uludag University, Medical Faculty, Department of Cardiology, Bursa, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11016014

Citation

Yesilbursa, D, et al. "Susceptibility of Apolipoprotein B-containing Lipoproteins to Oxidation and Antioxidant Status in Acute Coronary Syndromes." Clinical Cardiology, vol. 23, no. 9, 2000, pp. 655-8.
Yesilbursa D, Serdar Z, Dirican M, et al. Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes. Clin Cardiol. 2000;23(9):655-8.
Yesilbursa, D., Serdar, Z., Dirican, M., Serdar, A., Güllülü, S., & Cordan, J. (2000). Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes. Clinical Cardiology, 23(9), 655-8.
Yesilbursa D, et al. Susceptibility of Apolipoprotein B-containing Lipoproteins to Oxidation and Antioxidant Status in Acute Coronary Syndromes. Clin Cardiol. 2000;23(9):655-8. PubMed PMID: 11016014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes. AU - Yesilbursa,D, AU - Serdar,Z, AU - Dirican,M, AU - Serdar,A, AU - Güllülü,S, AU - Cordan,J, PY - 2000/10/4/pubmed PY - 2001/2/28/medline PY - 2000/10/4/entrez SP - 655 EP - 8 JF - Clinical cardiology JO - Clin Cardiol VL - 23 IS - 9 N2 - BACKGROUND: Oxidized lipoproteins may play an important role in the pathogenesis of atherosclerosis, and it has been shown that antioxidants have a protective effect against the progression of atherosclerosis. HYPOTHESIS: The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris. METHODS: The study population included 70 patients with acute coronary syndromes (14 with recent acute myocardial infarction and 56 with unstable angina pectoris), 105 patients with stable angina pectoris, and 75 control subjects. In addition to conventional lipid and lipoprotein analysis, the susceptibility of apolipoprotein B-containing lipoproteins to in vitro oxidation (lag phase) and plasma vitamin E and total carotene levels was measured. RESULTS: The lag phase was significantly shorter in patients with acute coronary syndromes (45 +/- 12 min) than in patients with stable angina pectoris (51 +/- 10 min) and in control subjects (58 +/- 9 min) (p < 0.0001). Both plasma vitamin E and total carotene levels were lowest in patients with acute coronary syndromes (1.11 +/- 0.32 mg/dl and 119 +/- 32 micrograms/dl, respectively), followed by patients with stable angina pectoris (1.25 +/- 0.37 mg/dl and 132 +/- 37 micrograms/dl) and then controls (1.52 +/- 0.31 mg/dl and 167 +/- 41 micrograms/dl). CONCLUSIONS: These data suggest that there is an intense oxidative process and a lower antioxidant status in acute coronary syndromes. This may lead to plaque instability due to the activation of the inflammatory response in coronary atherosclerotic lesions. SN - 0160-9289 UR - https://www.unboundmedicine.com/medline/citation/11016014/Susceptibility_of_apolipoprotein_B_containing_lipoproteins_to_oxidation_and_antioxidant_status_in_acute_coronary_syndromes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0160-9289&amp;date=2000&amp;volume=23&amp;issue=9&amp;spage=655 DB - PRIME DP - Unbound Medicine ER -