Tags

Type your tag names separated by a space and hit enter

Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease.
Neurobiol Aging 2000 Sep-Oct; 21(5):735-40NA

Abstract

We investigated the usefulness of cerebrospinal fluid (CSF) beta-amyloid42 (Abeta42), beta-amyloid40 (Abeta40) and tau analyses in the diagnosis of Alzheimer's disease (AD). The study included 41 definite AD cases, 80 patients with probable AD. 27 with other dementias and 39 neurological controls. Abeta42, Abeta340 and tau protein concentrations in CSF were measured of using ELISA assays. Abeta42 levels were decreased and tau increased in AD. Combination of Abeta42 and tau resulted a sensitivity of 50.4% for AD and specificities of 94.8% for controls and 85.2% for other dementias. Ninety-one percent of the patients with Abeta42 below the cutoff value (340 pg/ml) and tau above the cutoff value (380 pg/ml) had AD. AD patients carrying apoE epsilon4 allele had lower Abeta42 (P < 0.005) and higher tau (P < 0.05) levels than those without an E4 allele, and 18 (81.8%) of the 22 AD patients who had normal Abeta42 and tau levels were apoE e4 allele non-carriers. Low Abeta42 and high tau concentration in CSF strongly support the diagnosis of AD. Measurement of Abeta42 may help the early diagnosis of cases at risk for AD such as apoE E4 allele carriers.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11016543

Citation

Tapiola, T, et al. "Relationship Between apoE Genotype and CSF Beta-amyloid (1-42) and Tau in Patients With Probable and Definite Alzheimer's Disease." Neurobiology of Aging, vol. 21, no. 5, 2000, pp. 735-40.
Tapiola T, Pirttilä T, Mehta PD, et al. Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. Neurobiol Aging. 2000;21(5):735-40.
Tapiola, T., Pirttilä, T., Mehta, P. D., Alafuzofff, I., Lehtovirta, M., & Soininen, H. (2000). Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. Neurobiology of Aging, 21(5), pp. 735-40.
Tapiola T, et al. Relationship Between apoE Genotype and CSF Beta-amyloid (1-42) and Tau in Patients With Probable and Definite Alzheimer's Disease. Neurobiol Aging. 2000;21(5):735-40. PubMed PMID: 11016543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. AU - Tapiola,T, AU - Pirttilä,T, AU - Mehta,P D, AU - Alafuzofff,I, AU - Lehtovirta,M, AU - Soininen,H, PY - 2000/10/4/pubmed PY - 2001/2/28/medline PY - 2000/10/4/entrez SP - 735 EP - 40 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 21 IS - 5 N2 - We investigated the usefulness of cerebrospinal fluid (CSF) beta-amyloid42 (Abeta42), beta-amyloid40 (Abeta40) and tau analyses in the diagnosis of Alzheimer's disease (AD). The study included 41 definite AD cases, 80 patients with probable AD. 27 with other dementias and 39 neurological controls. Abeta42, Abeta340 and tau protein concentrations in CSF were measured of using ELISA assays. Abeta42 levels were decreased and tau increased in AD. Combination of Abeta42 and tau resulted a sensitivity of 50.4% for AD and specificities of 94.8% for controls and 85.2% for other dementias. Ninety-one percent of the patients with Abeta42 below the cutoff value (340 pg/ml) and tau above the cutoff value (380 pg/ml) had AD. AD patients carrying apoE epsilon4 allele had lower Abeta42 (P < 0.005) and higher tau (P < 0.05) levels than those without an E4 allele, and 18 (81.8%) of the 22 AD patients who had normal Abeta42 and tau levels were apoE e4 allele non-carriers. Low Abeta42 and high tau concentration in CSF strongly support the diagnosis of AD. Measurement of Abeta42 may help the early diagnosis of cases at risk for AD such as apoE E4 allele carriers. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/11016543/Relationship_between_apoE_genotype_and_CSF_beta_amyloid__1_42__and_tau_in_patients_with_probable_and_definite_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458000001640 DB - PRIME DP - Unbound Medicine ER -