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A central pattern generator underlies crawling in the medicinal leech.
J Comp Physiol A 2000 Jul-Aug; 186(7-8):631-43JC

Abstract

Crawling in the medicinal leech has previously been thought to require sensory feedback because the intact behavior is strongly modulated by sensory feedback and because semi-intact preparations will only crawl if they can move freely. Here we show that an isolated leech nerve cord can produce a crawling motor pattern similar to the one seen in semi-intact preparations, which consists of an anterior-to-posterior wave of alternating excitatory circular and longitudinal motor neuron bursts in each segment. The isolated cord also reproduces the patterns of activity seen in semi-intact preparations for several other kinds of cells: the dorsal inhibitor cell 1, the ventral excitor cell 4, and the annulus erector motor neuron. Because this correspondence is so strong, there must be a central pattern generator in the isolated cord that can produce the basic motor pattern for crawling without sensory feedback. A quantitative analysis of the isolated motor pattern, however, reveals that isolated and semi-intact preparations have longer periods than the intact behavior and that there are deficiencies in the timing of motor neuron bursts in the isolated pattern. These results suggest that sensory feedback modulates the isolated central pattern generator to help produce the normal motor pattern.

Authors+Show Affiliations

Program in Neurosciences, University of California, San Diego, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11016780

Citation

Eisenhart, F J., et al. "A Central Pattern Generator Underlies Crawling in the Medicinal Leech." Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology, vol. 186, no. 7-8, 2000, pp. 631-43.
Eisenhart FJ, Cacciatore TW, Kristan WB. A central pattern generator underlies crawling in the medicinal leech. J Comp Physiol A. 2000;186(7-8):631-43.
Eisenhart, F. J., Cacciatore, T. W., & Kristan, W. B. (2000). A central pattern generator underlies crawling in the medicinal leech. Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology, 186(7-8), pp. 631-43.
Eisenhart FJ, Cacciatore TW, Kristan WB. A Central Pattern Generator Underlies Crawling in the Medicinal Leech. J Comp Physiol A. 2000;186(7-8):631-43. PubMed PMID: 11016780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A central pattern generator underlies crawling in the medicinal leech. AU - Eisenhart,F J, AU - Cacciatore,T W, AU - Kristan,W B,Jr PY - 2000/10/4/pubmed PY - 2001/3/3/medline PY - 2000/10/4/entrez SP - 631 EP - 43 JF - Journal of comparative physiology. A, Sensory, neural, and behavioral physiology JO - J. Comp. Physiol. A VL - 186 IS - 7-8 N2 - Crawling in the medicinal leech has previously been thought to require sensory feedback because the intact behavior is strongly modulated by sensory feedback and because semi-intact preparations will only crawl if they can move freely. Here we show that an isolated leech nerve cord can produce a crawling motor pattern similar to the one seen in semi-intact preparations, which consists of an anterior-to-posterior wave of alternating excitatory circular and longitudinal motor neuron bursts in each segment. The isolated cord also reproduces the patterns of activity seen in semi-intact preparations for several other kinds of cells: the dorsal inhibitor cell 1, the ventral excitor cell 4, and the annulus erector motor neuron. Because this correspondence is so strong, there must be a central pattern generator in the isolated cord that can produce the basic motor pattern for crawling without sensory feedback. A quantitative analysis of the isolated motor pattern, however, reveals that isolated and semi-intact preparations have longer periods than the intact behavior and that there are deficiencies in the timing of motor neuron bursts in the isolated pattern. These results suggest that sensory feedback modulates the isolated central pattern generator to help produce the normal motor pattern. UR - https://www.unboundmedicine.com/medline/citation/11016780/A_central_pattern_generator_underlies_crawling_in_the_medicinal_leech_ DB - PRIME DP - Unbound Medicine ER -