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Multiple endocrine neoplasia type 1: from bedside to benchside.
J Med Invest. 2000 Aug; 47(3-4):108-17.JM

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic endocrine, and anterior pituitary tumors. MEN1 has two characteristics; a hormone excess and a sometimes lethal outcome due to malignant tumors. The recent identification of the MEN1 gene has opened the door to a much deeper understanding of this syndrome. Germline MEN1 mutations have been identified in most MEN1 families. They were not found, however, in families with familial pituitary tumors. Thus, studies with the MEN1 gene helped to establish that mutation of some other gene(s) is likely causative of the MEN1 phenocopy. These recent advances provide for the identification of mutant MEN1 gene carriers who are at a high risk of developing MEN1. The protein encoded by the MEN1 gene has been shown to function in the regulation of JunD-activated transcription but much still remains to be elucidated.

Authors+Show Affiliations

Otsuka Department of Molecular Nutrition, University of Tokushima School of Medicine, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11019489

Citation

Yoshimoto, K. "Multiple Endocrine Neoplasia Type 1: From Bedside to Benchside." The Journal of Medical Investigation : JMI, vol. 47, no. 3-4, 2000, pp. 108-17.
Yoshimoto K. Multiple endocrine neoplasia type 1: from bedside to benchside. J Med Invest. 2000;47(3-4):108-17.
Yoshimoto, K. (2000). Multiple endocrine neoplasia type 1: from bedside to benchside. The Journal of Medical Investigation : JMI, 47(3-4), 108-17.
Yoshimoto K. Multiple Endocrine Neoplasia Type 1: From Bedside to Benchside. J Med Invest. 2000;47(3-4):108-17. PubMed PMID: 11019489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple endocrine neoplasia type 1: from bedside to benchside. A1 - Yoshimoto,K, PY - 2000/10/6/pubmed PY - 2001/2/28/medline PY - 2000/10/6/entrez SP - 108 EP - 17 JF - The journal of medical investigation : JMI JO - J Med Invest VL - 47 IS - 3-4 N2 - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic endocrine, and anterior pituitary tumors. MEN1 has two characteristics; a hormone excess and a sometimes lethal outcome due to malignant tumors. The recent identification of the MEN1 gene has opened the door to a much deeper understanding of this syndrome. Germline MEN1 mutations have been identified in most MEN1 families. They were not found, however, in families with familial pituitary tumors. Thus, studies with the MEN1 gene helped to establish that mutation of some other gene(s) is likely causative of the MEN1 phenocopy. These recent advances provide for the identification of mutant MEN1 gene carriers who are at a high risk of developing MEN1. The protein encoded by the MEN1 gene has been shown to function in the regulation of JunD-activated transcription but much still remains to be elucidated. SN - 1343-1420 UR - https://www.unboundmedicine.com/medline/citation/11019489/Multiple_endocrine_neoplasia_type_1:_from_bedside_to_benchside_ L2 - http://www.diseaseinfosearch.org/result/4954 DB - PRIME DP - Unbound Medicine ER -