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Comparative study on the acceptability of two modern monophasic oral contraceptive preparations: 30 microgram ethinyl estradiol combined with 150 microgram desogestrel or 75 microgram gestodene.
Adv Contracept. 1999; 15(3):191-200.AC

Abstract

Cycle control and tolerability of two monophasic oral contraceptive pills containing 30 microg ethinyl estradiol (EE) with either 150 microg desogestrel (DSG) or 75 microg gestodene (GSD) were compared in women starting oral contraception. A minimum of 200 healthy women at risk for pregnancy were to be treated for a total of 6 cycles per patient in a prospective, randomized open parallel-group multicenter trial. Two hundred and forty-one subjects were randomized, 115 to DSG/EE and 126 to GSD/EE. Compliance to the study preparation was high (around 95%) in both groups and no pregnancies occurred during the study. Cycle control was excellent; there were no differences between the two groups with regard to incidence of spotting and breakthrough bleeding or duration and intensity of withdrawal bleeding. Side-effects were mild and in general comparable in the two groups. Both at baseline and during treatment, a higher proportion of women taking GSD/EE complained about breast tenderness. This resulted in more early withdrawals because of breast tenderness in the GSD/EE group. It was concluded that monophasic DSG/EE and GSD/EE are equally effective, have similar cycle control and both are generally well tolerated.

Authors+Show Affiliations

Clinica Ostetrica e Ginecologia, Universita degli Studi, La Sapienza, Roma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11019950

Citation

Zichella, L, et al. "Comparative Study On the Acceptability of Two Modern Monophasic Oral Contraceptive Preparations: 30 Microgram Ethinyl Estradiol Combined With 150 Microgram Desogestrel or 75 Microgram Gestodene." Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception, vol. 15, no. 3, 1999, pp. 191-200.
Zichella L, Sbrignadello C, Tomassini A, et al. Comparative study on the acceptability of two modern monophasic oral contraceptive preparations: 30 microgram ethinyl estradiol combined with 150 microgram desogestrel or 75 microgram gestodene. Adv Contracept. 1999;15(3):191-200.
Zichella, L., Sbrignadello, C., Tomassini, A., Di Lieto, A., Montoneri, C., Zarbo, G., Mancone, M., Pietrobattista, P., Bertoli, G., & Perrone, G. (1999). Comparative study on the acceptability of two modern monophasic oral contraceptive preparations: 30 microgram ethinyl estradiol combined with 150 microgram desogestrel or 75 microgram gestodene. Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception, 15(3), 191-200.
Zichella L, et al. Comparative Study On the Acceptability of Two Modern Monophasic Oral Contraceptive Preparations: 30 Microgram Ethinyl Estradiol Combined With 150 Microgram Desogestrel or 75 Microgram Gestodene. Adv Contracept. 1999;15(3):191-200. PubMed PMID: 11019950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study on the acceptability of two modern monophasic oral contraceptive preparations: 30 microgram ethinyl estradiol combined with 150 microgram desogestrel or 75 microgram gestodene. AU - Zichella,L, AU - Sbrignadello,C, AU - Tomassini,A, AU - Di Lieto,A, AU - Montoneri,C, AU - Zarbo,G, AU - Mancone,M, AU - Pietrobattista,P, AU - Bertoli,G, AU - Perrone,G, PY - 2000/10/6/pubmed PY - 2000/10/14/medline PY - 2000/10/6/entrez KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Contraceptive Usage KW - Desogestrel KW - Developed Countries KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Gestodene KW - Italy KW - Mediterranean Countries KW - Method Acceptability KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Prospective Studies KW - Research Methodology KW - Research Report KW - Southern Europe KW - Studies SP - 191 EP - 200 JF - Advances in contraception : the official journal of the Society for the Advancement of Contraception JO - Adv Contracept VL - 15 IS - 3 N2 - Cycle control and tolerability of two monophasic oral contraceptive pills containing 30 microg ethinyl estradiol (EE) with either 150 microg desogestrel (DSG) or 75 microg gestodene (GSD) were compared in women starting oral contraception. A minimum of 200 healthy women at risk for pregnancy were to be treated for a total of 6 cycles per patient in a prospective, randomized open parallel-group multicenter trial. Two hundred and forty-one subjects were randomized, 115 to DSG/EE and 126 to GSD/EE. Compliance to the study preparation was high (around 95%) in both groups and no pregnancies occurred during the study. Cycle control was excellent; there were no differences between the two groups with regard to incidence of spotting and breakthrough bleeding or duration and intensity of withdrawal bleeding. Side-effects were mild and in general comparable in the two groups. Both at baseline and during treatment, a higher proportion of women taking GSD/EE complained about breast tenderness. This resulted in more early withdrawals because of breast tenderness in the GSD/EE group. It was concluded that monophasic DSG/EE and GSD/EE are equally effective, have similar cycle control and both are generally well tolerated. SN - 0267-4874 UR - https://www.unboundmedicine.com/medline/citation/11019950/Comparative_study_on_the_acceptability_of_two_modern_monophasic_oral_contraceptive_preparations:_30_microgram_ethinyl_estradiol_combined_with_150_microgram_desogestrel_or_75_microgram_gestodene_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11019950.ui DB - PRIME DP - Unbound Medicine ER -