Tags

Type your tag names separated by a space and hit enter

p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy.
Hepatogastroenterology. 2000 Jul-Aug; 47(34):973-7.H

Abstract

BACKGROUND/AIMS

Intraductal papillary mucinous tumors, as a cystic disease in the pancreas, clinically has a more indolent and favorable course than invasive ductal pancreas carcinoma. However, some cases of intraductal papillary mucinous tumors show invasive and rapid progression like ductal pancreas carcinoma and the prognosis of such patients is sometimes poor. In the current study, we carried out immunohistochemical staining of intraductal papillary mucinous tumor tissues for p53 and investigated whether positive staining indicates tumor malignancies and has a prognostic value for intraductal papillary mucinous tumors.

METHODOLOGY

Nineteen (19) patients who underwent pancreatic resection under the diagnosis of intraductal papillary mucinous tumors at the Chiba University Hospital between April 1992 and December 1996 were studied. We performed immunohistochemical staining of p53 as well as of PCNA, Ki-67 and Bcl-2 using their respective antibodies. Pathological findings revealed that 9 cases were intraductal papillary adenoma, 9 were intraductal papillary adenocarcinoma, and one was invasive ductal papillary adenocarcinoma.

RESULTS

p53 expression could only be detected in the 1 case with invasive ductal papillary adenocarcinoma. Significant association could not be found between histological features and immunohistochemical staining of PCNA, Ki-67 and Bcl-2.

CONCLUSIONS

p53 protein expression could be detected after progression to invasive type of intraductal papillary mucinous tumors. The present results demonstrate that p53 expression might be an indicator of invasive progression in intraductal papillary mucinous tumors, and might represent a surgical indicator of intraductal papillary mucinous tumors.

Authors+Show Affiliations

2nd Department of Surgery, Chiba University School of Medicine, Japan. hkawahir@east.ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11020860

Citation

Kawahira, H, et al. "P53 Protein Expression in Intraductal Papillary Mucinous Tumors (IPMT) of the Pancreas as an Indicator of Tumor Malignancy." Hepato-gastroenterology, vol. 47, no. 34, 2000, pp. 973-7.
Kawahira H, Kobayashi S, Kaneko K, et al. P53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology. 2000;47(34):973-7.
Kawahira, H., Kobayashi, S., Kaneko, K., Asano, T., & Ochiai, T. (2000). P53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepato-gastroenterology, 47(34), 973-7.
Kawahira H, et al. P53 Protein Expression in Intraductal Papillary Mucinous Tumors (IPMT) of the Pancreas as an Indicator of Tumor Malignancy. Hepatogastroenterology. 2000 Jul-Aug;47(34):973-7. PubMed PMID: 11020860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. AU - Kawahira,H, AU - Kobayashi,S, AU - Kaneko,K, AU - Asano,T, AU - Ochiai,T, PY - 2000/10/6/pubmed PY - 2001/3/3/medline PY - 2000/10/6/entrez SP - 973 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 47 IS - 34 N2 - BACKGROUND/AIMS: Intraductal papillary mucinous tumors, as a cystic disease in the pancreas, clinically has a more indolent and favorable course than invasive ductal pancreas carcinoma. However, some cases of intraductal papillary mucinous tumors show invasive and rapid progression like ductal pancreas carcinoma and the prognosis of such patients is sometimes poor. In the current study, we carried out immunohistochemical staining of intraductal papillary mucinous tumor tissues for p53 and investigated whether positive staining indicates tumor malignancies and has a prognostic value for intraductal papillary mucinous tumors. METHODOLOGY: Nineteen (19) patients who underwent pancreatic resection under the diagnosis of intraductal papillary mucinous tumors at the Chiba University Hospital between April 1992 and December 1996 were studied. We performed immunohistochemical staining of p53 as well as of PCNA, Ki-67 and Bcl-2 using their respective antibodies. Pathological findings revealed that 9 cases were intraductal papillary adenoma, 9 were intraductal papillary adenocarcinoma, and one was invasive ductal papillary adenocarcinoma. RESULTS: p53 expression could only be detected in the 1 case with invasive ductal papillary adenocarcinoma. Significant association could not be found between histological features and immunohistochemical staining of PCNA, Ki-67 and Bcl-2. CONCLUSIONS: p53 protein expression could be detected after progression to invasive type of intraductal papillary mucinous tumors. The present results demonstrate that p53 expression might be an indicator of invasive progression in intraductal papillary mucinous tumors, and might represent a surgical indicator of intraductal papillary mucinous tumors. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/11020860/p53_protein_expression_in_intraductal_papillary_mucinous_tumors__IPMT__of_the_pancreas_as_an_indicator_of_tumor_malignancy_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -