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Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model.
Neuropeptides. 2000 Jun-Aug; 34(3-4):158-66.N

Abstract

Our previous studies have demonstrated that supraspinal glutamate receptors are differentially involved in the antinociception induced by morphine and beta-endorphin given intracerebroventricularly (i.c.v.) in the tail-flick and hot-plate tests. The formalin pain test was used in the present study. Injection of mice with formalin solution (2%, 10 microl) into the hindpaw intraplantarly produced the first (0-5 min) and second (20-40 min) phases of formalin responses. The formalin responses in the both phases were attenuated dose-dependently by morphine (0.125-1 microg) or beta-endorphin (0.125-1 microg) administered i.c.v. 5 min before. The antinociceptive effect of morphine was slightly more potent in the second phase whereas the effect of beta-endorphin was more pronounced in the first phase. MK-801 (0.1-1 microg), a non-competitive NMDA receptor antagonist, and CNQX (0.05-0.5 microg), a non-NMDA antagonist, given i.c.v., produced antinociceptive effect in the both phases, but only in a partial manner. Both MK-801 (0.05 microg) and CNQX (0.01 microg), at the dose which had no intrinsic effect, reversed the antinociceptive effect of beta-endorphin (1 microg) observed during the second, but not the first, phase partially but significantly. However, the antinociceptive effect of morphine (1 microg) was not affected by the same dose of MK-801 or CNQX given i.c.v. Our results indicate that, at the supraspinal level, both NMDA and non-NMDA receptors are involved in the production of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model.

Authors+Show Affiliations

Department of Pharmacology and Institute of Natural Medicine, College of Medicine, Hallym University, 1 Okchun-Dong, Chunchon, Kangwon-Do 200-702, S. Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11021975

Citation

Chung, K M., et al. "Supraspinal NMDA and non-NMDA Receptors Are Differentially Involved in the Production of Antinociception By Morphine and Beta-endorphin Administered Intracerebroventricularly in the Formalin Pain Model." Neuropeptides, vol. 34, no. 3-4, 2000, pp. 158-66.
Chung KM, Song DK, Huh SO, et al. Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model. Neuropeptides. 2000;34(3-4):158-66.
Chung, K. M., Song, D. K., Huh, S. O., Kim, Y. H., Choi, M. R., & Suh, H. W. (2000). Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model. Neuropeptides, 34(3-4), 158-66.
Chung KM, et al. Supraspinal NMDA and non-NMDA Receptors Are Differentially Involved in the Production of Antinociception By Morphine and Beta-endorphin Administered Intracerebroventricularly in the Formalin Pain Model. Neuropeptides. 2000 Jun-Aug;34(3-4):158-66. PubMed PMID: 11021975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model. AU - Chung,K M, AU - Song,D K, AU - Huh,S O, AU - Kim,Y H, AU - Choi,M R, AU - Suh,H W, PY - 2000/10/7/pubmed PY - 2001/5/5/medline PY - 2000/10/7/entrez SP - 158 EP - 66 JF - Neuropeptides JO - Neuropeptides VL - 34 IS - 3-4 N2 - Our previous studies have demonstrated that supraspinal glutamate receptors are differentially involved in the antinociception induced by morphine and beta-endorphin given intracerebroventricularly (i.c.v.) in the tail-flick and hot-plate tests. The formalin pain test was used in the present study. Injection of mice with formalin solution (2%, 10 microl) into the hindpaw intraplantarly produced the first (0-5 min) and second (20-40 min) phases of formalin responses. The formalin responses in the both phases were attenuated dose-dependently by morphine (0.125-1 microg) or beta-endorphin (0.125-1 microg) administered i.c.v. 5 min before. The antinociceptive effect of morphine was slightly more potent in the second phase whereas the effect of beta-endorphin was more pronounced in the first phase. MK-801 (0.1-1 microg), a non-competitive NMDA receptor antagonist, and CNQX (0.05-0.5 microg), a non-NMDA antagonist, given i.c.v., produced antinociceptive effect in the both phases, but only in a partial manner. Both MK-801 (0.05 microg) and CNQX (0.01 microg), at the dose which had no intrinsic effect, reversed the antinociceptive effect of beta-endorphin (1 microg) observed during the second, but not the first, phase partially but significantly. However, the antinociceptive effect of morphine (1 microg) was not affected by the same dose of MK-801 or CNQX given i.c.v. Our results indicate that, at the supraspinal level, both NMDA and non-NMDA receptors are involved in the production of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/11021975/Supraspinal_NMDA_and_non_NMDA_receptors_are_differentially_involved_in_the_production_of_antinociception_by_morphine_and_beta_endorphin_administered_intracerebroventricularly_in_the_formalin_pain_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(00)90805-9 DB - PRIME DP - Unbound Medicine ER -