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From analgesic intolerance to analgesic induced asthma: are there some determinants?
Allergol Immunopathol (Madr). 2000 Jul-Aug; 28(4):229-37.AI

Abstract

BACKGROUND

Analgesic intolerance (AI) sometimes appear alone and sometimes with bronchial asthma affecting about 10% of asthmatics and sometimes before and the other times after asthma.

OBJECTIVE

We investigated the possible clinical risk factors which might be affecting the transition from isolated AI to analgesic induced asthma (AIA).

METHODS

A total of 344 patients admitted to Hacettepe University Hospital Adult Allergy Unit between January 1991 and March 1999 and diagnosed with AI were enrolled in this survey. Patients having AIA (group I) (n = 191) were compared with the patients having AI without asthma (group II) (n = 153). The diagnosis of AI and AIA were made by history and oral provocation tests. A standard questionnaire was filled-in for all the patients.

RESULTS

The risk of AIA was increased with nasal polyp, and rhinosinusitis via OR's of 2.75 (95% CI: 1.09, 6.91), and 18.58 (95% CI: 9.86, 35.01), respectively. Having a pet, and ever smoking decreased the risk of AIA in the patients with AI via OR's of 0.53 (95% CI: 0.24, 1.17), and 0.37 (95% CI: 0.17, 0.80), respectively. The association of AIA and smoking was slightly modified by food intolerance (OR for ever smoked and food intolerance: 1.31, 95% CI: 0.40, 4.30).

CONCLUSION

There may be two different phenotypes of AI with different clinical features: one developing AIA (having nasal polyp and/or rhinosinusitis, and smoking if food allergy/intolerance is present), and the other AI without asthma (having pet, and could smoke). Findings of this study should be confirmed by further investigations.

Authors+Show Affiliations

Hacettepe University Hospital, Department of Chest Diseases, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11022270

Citation

Karakaya, G, et al. "From Analgesic Intolerance to Analgesic Induced Asthma: Are There some Determinants?" Allergologia Et Immunopathologia, vol. 28, no. 4, 2000, pp. 229-37.
Karakaya G, Demir AU, Kalyoncu AF. From analgesic intolerance to analgesic induced asthma: are there some determinants? Allergol Immunopathol (Madr). 2000;28(4):229-37.
Karakaya, G., Demir, A. U., & Kalyoncu, A. F. (2000). From analgesic intolerance to analgesic induced asthma: are there some determinants? Allergologia Et Immunopathologia, 28(4), 229-37.
Karakaya G, Demir AU, Kalyoncu AF. From Analgesic Intolerance to Analgesic Induced Asthma: Are There some Determinants. Allergol Immunopathol (Madr). 2000 Jul-Aug;28(4):229-37. PubMed PMID: 11022270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From analgesic intolerance to analgesic induced asthma: are there some determinants? AU - Karakaya,G, AU - Demir,A U, AU - Kalyoncu,A F, PY - 2000/10/7/pubmed PY - 2001/2/28/medline PY - 2000/10/7/entrez SP - 229 EP - 37 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 28 IS - 4 N2 - BACKGROUND: Analgesic intolerance (AI) sometimes appear alone and sometimes with bronchial asthma affecting about 10% of asthmatics and sometimes before and the other times after asthma. OBJECTIVE: We investigated the possible clinical risk factors which might be affecting the transition from isolated AI to analgesic induced asthma (AIA). METHODS: A total of 344 patients admitted to Hacettepe University Hospital Adult Allergy Unit between January 1991 and March 1999 and diagnosed with AI were enrolled in this survey. Patients having AIA (group I) (n = 191) were compared with the patients having AI without asthma (group II) (n = 153). The diagnosis of AI and AIA were made by history and oral provocation tests. A standard questionnaire was filled-in for all the patients. RESULTS: The risk of AIA was increased with nasal polyp, and rhinosinusitis via OR's of 2.75 (95% CI: 1.09, 6.91), and 18.58 (95% CI: 9.86, 35.01), respectively. Having a pet, and ever smoking decreased the risk of AIA in the patients with AI via OR's of 0.53 (95% CI: 0.24, 1.17), and 0.37 (95% CI: 0.17, 0.80), respectively. The association of AIA and smoking was slightly modified by food intolerance (OR for ever smoked and food intolerance: 1.31, 95% CI: 0.40, 4.30). CONCLUSION: There may be two different phenotypes of AI with different clinical features: one developing AIA (having nasal polyp and/or rhinosinusitis, and smoking if food allergy/intolerance is present), and the other AI without asthma (having pet, and could smoke). Findings of this study should be confirmed by further investigations. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/11022270/From_analgesic_intolerance_to_analgesic_induced_asthma:_are_there_some_determinants DB - PRIME DP - Unbound Medicine ER -