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Experience with the [13C2]oxalate absorption test.
Isotopes Environ Health Stud. 2000; 36(1):11-20.IE

Abstract

Hyperoxaluria is the most important risk factor for a formation of calcium oxalate-urinary stones. Usually, the bulk of oxalate will be formed in the human body, but in many patients the oxalate from food plays the decisive role. Conventionally, in urine the endogenous oxalate can not be distinguished from food derived oxalate. We have developed a standardized oxalate-absorption test, applying a physiological dose (50 mg disodium salt of [13C2]oxalic acid) of labelled oxalate. The assay has been published. Now we report on the first extensive applications of this test in 86 volunteers and 135 patients from different groups with calcium oxalate stones or an increased risk of the formation of such stones. In one-third of the patients with calcium oxalate-urinary stones an oxalate hyperabsorption was diagnosed. For these patients, a dietetic stone prophylaxis and/or therapy is indicated.

Authors+Show Affiliations

Medizinische Universitätsklinik I, Massenspektrometrie-Labor, Bonn, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11022322

Citation

von Unruh, G E., et al. "Experience With the [13C2]oxalate Absorption Test." Isotopes in Environmental and Health Studies, vol. 36, no. 1, 2000, pp. 11-20.
von Unruh GE, Voss S, Hesse A. Experience with the [13C2]oxalate absorption test. Isotopes Environ Health Stud. 2000;36(1):11-20.
von Unruh, G. E., Voss, S., & Hesse, A. (2000). Experience with the [13C2]oxalate absorption test. Isotopes in Environmental and Health Studies, 36(1), 11-20.
von Unruh GE, Voss S, Hesse A. Experience With the [13C2]oxalate Absorption Test. Isotopes Environ Health Stud. 2000;36(1):11-20. PubMed PMID: 11022322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experience with the [13C2]oxalate absorption test. AU - von Unruh,G E, AU - Voss,S, AU - Hesse,A, PY - 2000/10/7/pubmed PY - 2001/2/28/medline PY - 2000/10/7/entrez SP - 11 EP - 20 JF - Isotopes in environmental and health studies JO - Isotopes Environ Health Stud VL - 36 IS - 1 N2 - Hyperoxaluria is the most important risk factor for a formation of calcium oxalate-urinary stones. Usually, the bulk of oxalate will be formed in the human body, but in many patients the oxalate from food plays the decisive role. Conventionally, in urine the endogenous oxalate can not be distinguished from food derived oxalate. We have developed a standardized oxalate-absorption test, applying a physiological dose (50 mg disodium salt of [13C2]oxalic acid) of labelled oxalate. The assay has been published. Now we report on the first extensive applications of this test in 86 volunteers and 135 patients from different groups with calcium oxalate stones or an increased risk of the formation of such stones. In one-third of the patients with calcium oxalate-urinary stones an oxalate hyperabsorption was diagnosed. For these patients, a dietetic stone prophylaxis and/or therapy is indicated. SN - 1025-6016 UR - https://www.unboundmedicine.com/medline/citation/11022322/Experience_with_the_[13C2]oxalate_absorption_test_ L2 - http://www.tandfonline.com/doi/full/10.1080/10256010008032929 DB - PRIME DP - Unbound Medicine ER -