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A meta-analysis of Parkinson's disease and exposure to pesticides.
Neurotoxicology 2000; 21(4):435-40N

Abstract

This study examined the association between Parkinson's disease (PD) and exposure to pesticides. A series of meta-analysis of peer-reviewed studies were performed, using 19 studies published between 1989 and 1999. Prior to the meta-analysis, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random effect model. The majority of the studies reported consistent elevation in the risk of PD with exposure to pesticides. The combined OR studies was 1.94 [95% confidence interval (95% CI) 1.49-2.53] for all the studies, and 2.15 (95% CI 1.14-4.05) for studies performed in United States. Although the risk of PD increased with increased duration of exposure to pesticides, no significant dose-response relation was established, and no specific type of pesticide was identified. Our findings suggest that exposure to pesticides may be a significant risk factor for developing PD.

Authors+Show Affiliations

Department of Public Health, Medical College of Ohio, Toledo, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

11022853

Citation

Priyadarshi, A, et al. "A Meta-analysis of Parkinson's Disease and Exposure to Pesticides." Neurotoxicology, vol. 21, no. 4, 2000, pp. 435-40.
Priyadarshi A, Khuder SA, Schaub EA, et al. A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology. 2000;21(4):435-40.
Priyadarshi, A., Khuder, S. A., Schaub, E. A., & Shrivastava, S. (2000). A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology, 21(4), pp. 435-40.
Priyadarshi A, et al. A Meta-analysis of Parkinson's Disease and Exposure to Pesticides. Neurotoxicology. 2000;21(4):435-40. PubMed PMID: 11022853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis of Parkinson's disease and exposure to pesticides. AU - Priyadarshi,A, AU - Khuder,S A, AU - Schaub,E A, AU - Shrivastava,S, PY - 2000/10/7/pubmed PY - 2001/3/3/medline PY - 2000/10/7/entrez SP - 435 EP - 40 JF - Neurotoxicology JO - Neurotoxicology VL - 21 IS - 4 N2 - This study examined the association between Parkinson's disease (PD) and exposure to pesticides. A series of meta-analysis of peer-reviewed studies were performed, using 19 studies published between 1989 and 1999. Prior to the meta-analysis, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random effect model. The majority of the studies reported consistent elevation in the risk of PD with exposure to pesticides. The combined OR studies was 1.94 [95% confidence interval (95% CI) 1.49-2.53] for all the studies, and 2.15 (95% CI 1.14-4.05) for studies performed in United States. Although the risk of PD increased with increased duration of exposure to pesticides, no significant dose-response relation was established, and no specific type of pesticide was identified. Our findings suggest that exposure to pesticides may be a significant risk factor for developing PD. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/11022853/A_meta_analysis_of_Parkinson's_disease_and_exposure_to_pesticides_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -