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Contralateral effect of topical beta-adrenergic antagonists in initial one-eyed trials in the ocular hypertension treatment study.
Am J Ophthalmol 2000; 130(4):441-53AJ

Abstract

PURPOSE

To evaluate the magnitude of the contralateral effect of topically administered beta-blockers on intraocular pressure.

METHODS

The Ocular Hypertension Treatment Study enrolled 1,636 subjects. Of these, 817 subjects were randomized to receive topical ocular hypotensive medication and 819 subjects were randomized to close observation (i.e., no topical medication). We compared the intraocular pressure of the contralateral eye of subjects at the baseline visit and after an initial one-eyed therapeutic trial of topical beta-blockers. We examined differences between baseline and follow-up intraocular pressure in untreated eyes of subjects randomized to close observation.

RESULTS

The mean reduction in intraocular pressure in the beta-blocker-treated eyes was -5.9 +/- 3. 4 mm Hg (-22% +/- 12%; Student t test, P <.0001). In the contralateral eyes, mean intraocular pressure reduction was -1.5 +/- 3.0 mm Hg (-5.8% +/- 12%; P <.0001). Of the contralateral eyes, 35% showed a reduction of 3 mm Hg or more, and 10% showed a reduction of 6 mm Hg or more. The contralateral effect of the relatively selective beta-blocker betaxolol did not differ from that of any of the nonselective beta-blockers. Factors associated with the magnitude of the contralateral effect were the degree of intraocular pressure reduction in the treated eye and baseline intraocular pressure of the contralateral eye. In the close observation group, no significant reduction in intraocular pressure was noted between the baseline and follow-up visit.

CONCLUSIONS

The contralateral effect is important in clinical practice and in clinical trials when the hypotensive effect of a topical beta-blocker is evaluated by means of a one-eyed therapeutic trial.

Authors+Show Affiliations

Department of Ophthalmology, Scheie Eye Institute/University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11024416

Citation

Piltz, J, et al. "Contralateral Effect of Topical Beta-adrenergic Antagonists in Initial One-eyed Trials in the Ocular Hypertension Treatment Study." American Journal of Ophthalmology, vol. 130, no. 4, 2000, pp. 441-53.
Piltz J, Gross R, Shin DH, et al. Contralateral effect of topical beta-adrenergic antagonists in initial one-eyed trials in the ocular hypertension treatment study. Am J Ophthalmol. 2000;130(4):441-53.
Piltz, J., Gross, R., Shin, D. H., Beiser, J. A., Dorr, D. A., Kass, M. A., & Gordon, M. O. (2000). Contralateral effect of topical beta-adrenergic antagonists in initial one-eyed trials in the ocular hypertension treatment study. American Journal of Ophthalmology, 130(4), pp. 441-53.
Piltz J, et al. Contralateral Effect of Topical Beta-adrenergic Antagonists in Initial One-eyed Trials in the Ocular Hypertension Treatment Study. Am J Ophthalmol. 2000;130(4):441-53. PubMed PMID: 11024416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contralateral effect of topical beta-adrenergic antagonists in initial one-eyed trials in the ocular hypertension treatment study. AU - Piltz,J, AU - Gross,R, AU - Shin,D H, AU - Beiser,J A, AU - Dorr,D A, AU - Kass,M A, AU - Gordon,M O, PY - 2000/10/12/pubmed PY - 2001/2/28/medline PY - 2000/10/12/entrez SP - 441 EP - 53 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 130 IS - 4 N2 - PURPOSE: To evaluate the magnitude of the contralateral effect of topically administered beta-blockers on intraocular pressure. METHODS: The Ocular Hypertension Treatment Study enrolled 1,636 subjects. Of these, 817 subjects were randomized to receive topical ocular hypotensive medication and 819 subjects were randomized to close observation (i.e., no topical medication). We compared the intraocular pressure of the contralateral eye of subjects at the baseline visit and after an initial one-eyed therapeutic trial of topical beta-blockers. We examined differences between baseline and follow-up intraocular pressure in untreated eyes of subjects randomized to close observation. RESULTS: The mean reduction in intraocular pressure in the beta-blocker-treated eyes was -5.9 +/- 3. 4 mm Hg (-22% +/- 12%; Student t test, P <.0001). In the contralateral eyes, mean intraocular pressure reduction was -1.5 +/- 3.0 mm Hg (-5.8% +/- 12%; P <.0001). Of the contralateral eyes, 35% showed a reduction of 3 mm Hg or more, and 10% showed a reduction of 6 mm Hg or more. The contralateral effect of the relatively selective beta-blocker betaxolol did not differ from that of any of the nonselective beta-blockers. Factors associated with the magnitude of the contralateral effect were the degree of intraocular pressure reduction in the treated eye and baseline intraocular pressure of the contralateral eye. In the close observation group, no significant reduction in intraocular pressure was noted between the baseline and follow-up visit. CONCLUSIONS: The contralateral effect is important in clinical practice and in clinical trials when the hypotensive effect of a topical beta-blocker is evaluated by means of a one-eyed therapeutic trial. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/11024416/Contralateral_effect_of_topical_beta_adrenergic_antagonists_in_initial_one_eyed_trials_in_the_ocular_hypertension_treatment_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939400005274 DB - PRIME DP - Unbound Medicine ER -