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[Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement].
Med Klin (Munich) 2000; 95(9):477-81MK

Abstract

BACKGROUND

Hyperhomocysteinemia has been increasingly recognized as an important risk factor for elevated atherosclerotic vascular disease in chronic renal failure. We measured in patients with chronic renal failure homocysteine and metabolites of its 2 metabolic pathways, transulfuration (cystathionine, cysteine) and remethylation (methionine, methylmalonic acid, 2-methylcitric acid).

PATIENTS AND METHODS

Eleven patients on conservative treatment (creatinine clearance 10 to 30 ml/min) and 50 chronic uremic subjects on regular hemodialysis were included in the study. Twenty-two of the dialysis patients received daily oral multivitamin supplementation containing 10 mg vitamin B6, 6 micrograms vitamin B12, and 1 mg folic acid during the last year before the study started.

RESULTS

In the hemodialysis group homocysteine levels were higher compared with the patients on conservative treatment. Hemodialysis patients with additional vitamin supplementation showed significantly lower homocysteine levels than those without. The pattern of metabolites was different to these results: all metabolites were higher in hemodialysis patients, too (significant for cysteine and methionine), but vitamin supplementation failed to lower all metabolites.

CONCLUSION

Analysis of metabolites additional to homocysteine levels may help to understand different results in evaluation of atherosclerotic risk of hyperhomocysteinemia in chronic renal failure.

Authors+Show Affiliations

Universitätsklinik Marienhospital Herne, Ruhr-Universität Bochum. walter.zidek@ruhr-univ-bochumNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

11028163

Citation

Henning, B F., et al. "[Homocysteine and Its Metabolites in Chronic Renal Insufficiency and the Effect of a Vitamin Replacement]." Medizinische Klinik (Munich, Germany : 1983), vol. 95, no. 9, 2000, pp. 477-81.
Henning BF, Tepel M, Graefe U, et al. [Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement]. Med Klin (Munich). 2000;95(9):477-81.
Henning, B. F., Tepel, M., Graefe, U., & Zidek, W. (2000). [Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement]. Medizinische Klinik (Munich, Germany : 1983), 95(9), pp. 477-81.
Henning BF, et al. [Homocysteine and Its Metabolites in Chronic Renal Insufficiency and the Effect of a Vitamin Replacement]. Med Klin (Munich). 2000 Sep 15;95(9):477-81. PubMed PMID: 11028163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement]. AU - Henning,B F, AU - Tepel,M, AU - Graefe,U, AU - Zidek,W, PY - 2000/10/12/pubmed PY - 2001/2/28/medline PY - 2000/10/12/entrez SP - 477 EP - 81 JF - Medizinische Klinik (Munich, Germany : 1983) JO - Med. Klin. (Munich) VL - 95 IS - 9 N2 - BACKGROUND: Hyperhomocysteinemia has been increasingly recognized as an important risk factor for elevated atherosclerotic vascular disease in chronic renal failure. We measured in patients with chronic renal failure homocysteine and metabolites of its 2 metabolic pathways, transulfuration (cystathionine, cysteine) and remethylation (methionine, methylmalonic acid, 2-methylcitric acid). PATIENTS AND METHODS: Eleven patients on conservative treatment (creatinine clearance 10 to 30 ml/min) and 50 chronic uremic subjects on regular hemodialysis were included in the study. Twenty-two of the dialysis patients received daily oral multivitamin supplementation containing 10 mg vitamin B6, 6 micrograms vitamin B12, and 1 mg folic acid during the last year before the study started. RESULTS: In the hemodialysis group homocysteine levels were higher compared with the patients on conservative treatment. Hemodialysis patients with additional vitamin supplementation showed significantly lower homocysteine levels than those without. The pattern of metabolites was different to these results: all metabolites were higher in hemodialysis patients, too (significant for cysteine and methionine), but vitamin supplementation failed to lower all metabolites. CONCLUSION: Analysis of metabolites additional to homocysteine levels may help to understand different results in evaluation of atherosclerotic risk of hyperhomocysteinemia in chronic renal failure. SN - 0723-5003 UR - https://www.unboundmedicine.com/medline/citation/11028163/[Homocysteine_and_its_metabolites_in_chronic_renal_insufficiency_and_the_effect_of_a_vitamin_replacement]_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -