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Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease.
Arterioscler Thromb Vasc Biol 2000; 20(10):2243-7AT

Abstract

Recent studies have established oxidative modification of low density lipoprotein (LDL) as an important atherogenic factor. We examined the clinical relevance of circulating oxidized LDL (OxLDL) levels in atherosclerotic disease by an enzyme immunoassay with use of specific antibodies against OxLDL (FOH1a/DLH3) and apolipoprotein B. Plasma OxLDL levels were significantly higher in patients with coronary heart disease (n=65) than in control subjects (n=181; 201. 3+/-11.2 versus 112.4+/-3.3 U/dL, respectively; P<0.01). OxLDL levels were not associated with age, sex, total cholesterol, or apolipoprotein B levels in normal control subjects. Our results suggest that circulating OxLDL may be a possible biochemical risk marker for coronary heart disease.

Authors+Show Affiliations

Second Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11031210

Citation

Toshima, S, et al. "Circulating Oxidized Low Density Lipoprotein Levels. a Biochemical Risk Marker for Coronary Heart Disease." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 10, 2000, pp. 2243-7.
Toshima S, Hasegawa A, Kurabayashi M, et al. Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. Arterioscler Thromb Vasc Biol. 2000;20(10):2243-7.
Toshima, S., Hasegawa, A., Kurabayashi, M., Itabe, H., Takano, T., Sugano, J., ... Nagai, R. (2000). Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(10), pp. 2243-7.
Toshima S, et al. Circulating Oxidized Low Density Lipoprotein Levels. a Biochemical Risk Marker for Coronary Heart Disease. Arterioscler Thromb Vasc Biol. 2000;20(10):2243-7. PubMed PMID: 11031210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. AU - Toshima,S, AU - Hasegawa,A, AU - Kurabayashi,M, AU - Itabe,H, AU - Takano,T, AU - Sugano,J, AU - Shimamura,K, AU - Kimura,J, AU - Michishita,I, AU - Suzuki,T, AU - Nagai,R, PY - 2000/10/14/pubmed PY - 2001/2/28/medline PY - 2000/10/14/entrez SP - 2243 EP - 7 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 20 IS - 10 N2 - Recent studies have established oxidative modification of low density lipoprotein (LDL) as an important atherogenic factor. We examined the clinical relevance of circulating oxidized LDL (OxLDL) levels in atherosclerotic disease by an enzyme immunoassay with use of specific antibodies against OxLDL (FOH1a/DLH3) and apolipoprotein B. Plasma OxLDL levels were significantly higher in patients with coronary heart disease (n=65) than in control subjects (n=181; 201. 3+/-11.2 versus 112.4+/-3.3 U/dL, respectively; P<0.01). OxLDL levels were not associated with age, sex, total cholesterol, or apolipoprotein B levels in normal control subjects. Our results suggest that circulating OxLDL may be a possible biochemical risk marker for coronary heart disease. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/11031210/Circulating_oxidized_low_density_lipoprotein_levels__A_biochemical_risk_marker_for_coronary_heart_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11031210.ui DB - PRIME DP - Unbound Medicine ER -