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Elevated chemokine levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia.
J Allergy Clin Immunol. 2000 Oct; 106(4):730-6.JA

Abstract

BACKGROUND

Allergic lung inflammation is caused by accumulation and activation of different leukocyte subsets, such as eosinophils and T lymphocytes, in the lung. The chemokines are a large group of chemotactic cytokines that regulate leukocyte trafficking and may play an important role in allergic lung inflammation.

OBJECTIVE

The purpose of this study was to evaluate the role of various chemokines, including eotaxin, RANTES, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1beta, and IL-8 in the pathogenesis of eosinophilic pneumonia (EP).

METHODS

The concentrations of eotaxin, RANTES, MCP-1, MIP-1beta, and IL-8 in bronchoalveolar lavage fluid (BALF) were measured by using ELISA in 15 patients with EP, 10 with idiopathic pulmonary fibrosis, 10 with sarcoidosis, and 11 healthy volunteers.

RESULTS

Eotaxin in BALF was high only in patients with EP, and its level correlated significantly with the number of eosinophils in BALF of patients with EP and healthy volunteers. MCP-1 and MIP-1beta in BALF were preferentially increased in patients with EP. There was a significant correlation between MCP-1 levels and the number of macrophages in BALF of patients with EP and healthy volunteers.

CONCLUSION

Our findings suggest that these CC chemokines contribute to the pathogenesis of EP through the specific recruitment of leukocyte subsets in the lung.

Authors+Show Affiliations

Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11031344

Citation

Katoh, S, et al. "Elevated Chemokine Levels in Bronchoalveolar Lavage Fluid of Patients With Eosinophilic Pneumonia." The Journal of Allergy and Clinical Immunology, vol. 106, no. 4, 2000, pp. 730-6.
Katoh S, Matsumoto N, Fukushima K, et al. Elevated chemokine levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. J Allergy Clin Immunol. 2000;106(4):730-6.
Katoh, S., Matsumoto, N., Fukushima, K., Mukae, H., Kadota, J. I., Kohno, S., & Matsukura, S. (2000). Elevated chemokine levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. The Journal of Allergy and Clinical Immunology, 106(4), 730-6.
Katoh S, et al. Elevated Chemokine Levels in Bronchoalveolar Lavage Fluid of Patients With Eosinophilic Pneumonia. J Allergy Clin Immunol. 2000;106(4):730-6. PubMed PMID: 11031344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated chemokine levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. AU - Katoh,S, AU - Matsumoto,N, AU - Fukushima,K, AU - Mukae,H, AU - Kadota,J I, AU - Kohno,S, AU - Matsukura,S, PY - 2000/10/14/pubmed PY - 2001/2/28/medline PY - 2000/10/14/entrez SP - 730 EP - 6 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 106 IS - 4 N2 - BACKGROUND: Allergic lung inflammation is caused by accumulation and activation of different leukocyte subsets, such as eosinophils and T lymphocytes, in the lung. The chemokines are a large group of chemotactic cytokines that regulate leukocyte trafficking and may play an important role in allergic lung inflammation. OBJECTIVE: The purpose of this study was to evaluate the role of various chemokines, including eotaxin, RANTES, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1beta, and IL-8 in the pathogenesis of eosinophilic pneumonia (EP). METHODS: The concentrations of eotaxin, RANTES, MCP-1, MIP-1beta, and IL-8 in bronchoalveolar lavage fluid (BALF) were measured by using ELISA in 15 patients with EP, 10 with idiopathic pulmonary fibrosis, 10 with sarcoidosis, and 11 healthy volunteers. RESULTS: Eotaxin in BALF was high only in patients with EP, and its level correlated significantly with the number of eosinophils in BALF of patients with EP and healthy volunteers. MCP-1 and MIP-1beta in BALF were preferentially increased in patients with EP. There was a significant correlation between MCP-1 levels and the number of macrophages in BALF of patients with EP and healthy volunteers. CONCLUSION: Our findings suggest that these CC chemokines contribute to the pathogenesis of EP through the specific recruitment of leukocyte subsets in the lung. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/11031344/Elevated_chemokine_levels_in_bronchoalveolar_lavage_fluid_of_patients_with_eosinophilic_pneumonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(00)76106-9 DB - PRIME DP - Unbound Medicine ER -