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Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP).
Int J Obes Relat Metab Disord. 2000 Sep; 24(9):1097-106.IJ

Abstract

OBJECTIVE

To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP).

SUBJECTS

Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<1.1 mmol/l; %LDL-3>40% total LDL).

DESIGN

Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken.

OUTCOME MEASURES

BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype.

RESULTS

The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to -0.36).

CONCLUSION

In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP.

Authors+Show Affiliations

Department of Food Science and Technology, University of Reading, Whiteknights, UK. a.m.minihane@afnovell.reading.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11033977

Citation

Minihane, A M., et al. "Lack of Association Between Lipaemia and Central Adiposity in Subjects With an Atherogenic Lipoprotein Phenotype (ALP)." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 24, no. 9, 2000, pp. 1097-106.
Minihane AM, Khan S, Talmud PJ, et al. Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP). Int J Obes Relat Metab Disord. 2000;24(9):1097-106.
Minihane, A. M., Khan, S., Talmud, P. J., Williams, D. L., Wright, J. W., Murphy, M. C., Griffin, B. A., & Williams, C. M. (2000). Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP). International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 24(9), 1097-106.
Minihane AM, et al. Lack of Association Between Lipaemia and Central Adiposity in Subjects With an Atherogenic Lipoprotein Phenotype (ALP). Int J Obes Relat Metab Disord. 2000;24(9):1097-106. PubMed PMID: 11033977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP). AU - Minihane,A M, AU - Khan,S, AU - Talmud,P J, AU - Williams,D L, AU - Wright,J W, AU - Murphy,M C, AU - Griffin,B A, AU - Williams,C M, PY - 2000/10/18/pubmed PY - 2001/2/28/medline PY - 2000/10/18/entrez SP - 1097 EP - 106 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int J Obes Relat Metab Disord VL - 24 IS - 9 N2 - OBJECTIVE: To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP). SUBJECTS: Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<1.1 mmol/l; %LDL-3>40% total LDL). DESIGN: Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken. OUTCOME MEASURES: BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype. RESULTS: The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to -0.36). CONCLUSION: In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP. UR - https://www.unboundmedicine.com/medline/citation/11033977/Lack_of_association_between_lipaemia_and_central_adiposity_in_subjects_with_an_atherogenic_lipoprotein_phenotype__ALP__ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -