Tags

Type your tag names separated by a space and hit enter

Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease.

Abstract

A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin concentration) in patients with chronic stable or unstable coronary disease and in a group of age-matched controls. Three groups of individuals were studied: a) 24 healthy subjects (mean age: 63 +/- 13 yr); b) 32 patients with chronic, stable, coronary disease (62 +/- 11 yr); and c) 27 patients with unstable angina (62 +/- 12 yr). For 6-sulphatoxymelatonin measurement, urine was collected from 18:00 to 06:00 hr, within 48 hr of hospitalization in the case of unstable angina. 6-Sulphatoxymelatonin was measured by a specific radioimmunoassay. Urinary 6-sulphatoxymelatonin excretion was significantly lower in unstable angina patients than in healthy subjects or in patients with stable angina. 6-Sulphatoxymelatonin correlated negatively with age in healthy subjects, but not in coronary patients. 6-Sulphatoxymelatonin excretion in patients treated with beta-adrenoceptor blockers did not differ significantly from coronary patients not receiving beta-blockers. The results indicate that patients with coronary disease have a low melatonin production rate, with greater decreases in those with higher risk of cardiac infarction and/or death.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    División Cardiología, Hospital Ramos Jejía, Buenos Aires, Argentina.

    , , , , ,

    Source

    Journal of pineal research 29:3 2000 Oct pg 138-42

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Coronary Disease
    Female
    Humans
    Male
    Melatonin
    Middle Aged
    Radioimmunoassay

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11034110

    Citation

    Girotti, L, et al. "Low Urinary 6-sulphatoxymelatonin Levels in Patients With Coronary Artery Disease." Journal of Pineal Research, vol. 29, no. 3, 2000, pp. 138-42.
    Girotti L, Lago M, Ianovsky O, et al. Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. J Pineal Res. 2000;29(3):138-42.
    Girotti, L., Lago, M., Ianovsky, O., Carbajales, J., Elizari, M. V., Brusco, L. I., & Cardinali, D. P. (2000). Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. Journal of Pineal Research, 29(3), pp. 138-42.
    Girotti L, et al. Low Urinary 6-sulphatoxymelatonin Levels in Patients With Coronary Artery Disease. J Pineal Res. 2000;29(3):138-42. PubMed PMID: 11034110.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. AU - Girotti,L, AU - Lago,M, AU - Ianovsky,O, AU - Carbajales,J, AU - Elizari,M V, AU - Brusco,L I, AU - Cardinali,D P, PY - 2000/10/18/pubmed PY - 2001/2/28/medline PY - 2000/10/18/entrez SP - 138 EP - 42 JF - Journal of pineal research JO - J. Pineal Res. VL - 29 IS - 3 N2 - A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin concentration) in patients with chronic stable or unstable coronary disease and in a group of age-matched controls. Three groups of individuals were studied: a) 24 healthy subjects (mean age: 63 +/- 13 yr); b) 32 patients with chronic, stable, coronary disease (62 +/- 11 yr); and c) 27 patients with unstable angina (62 +/- 12 yr). For 6-sulphatoxymelatonin measurement, urine was collected from 18:00 to 06:00 hr, within 48 hr of hospitalization in the case of unstable angina. 6-Sulphatoxymelatonin was measured by a specific radioimmunoassay. Urinary 6-sulphatoxymelatonin excretion was significantly lower in unstable angina patients than in healthy subjects or in patients with stable angina. 6-Sulphatoxymelatonin correlated negatively with age in healthy subjects, but not in coronary patients. 6-Sulphatoxymelatonin excretion in patients treated with beta-adrenoceptor blockers did not differ significantly from coronary patients not receiving beta-blockers. The results indicate that patients with coronary disease have a low melatonin production rate, with greater decreases in those with higher risk of cardiac infarction and/or death. SN - 0742-3098 UR - https://www.unboundmedicine.com/medline/citation/11034110/Low_urinary_6_sulphatoxymelatonin_levels_in_patients_with_coronary_artery_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0742-3098&date=2000&volume=29&issue=3&spage=138 DB - PRIME DP - Unbound Medicine ER -