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Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease.
J Pineal Res 2000; 29(3):138-42JP

Abstract

A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin concentration) in patients with chronic stable or unstable coronary disease and in a group of age-matched controls. Three groups of individuals were studied: a) 24 healthy subjects (mean age: 63 +/- 13 yr); b) 32 patients with chronic, stable, coronary disease (62 +/- 11 yr); and c) 27 patients with unstable angina (62 +/- 12 yr). For 6-sulphatoxymelatonin measurement, urine was collected from 18:00 to 06:00 hr, within 48 hr of hospitalization in the case of unstable angina. 6-Sulphatoxymelatonin was measured by a specific radioimmunoassay. Urinary 6-sulphatoxymelatonin excretion was significantly lower in unstable angina patients than in healthy subjects or in patients with stable angina. 6-Sulphatoxymelatonin correlated negatively with age in healthy subjects, but not in coronary patients. 6-Sulphatoxymelatonin excretion in patients treated with beta-adrenoceptor blockers did not differ significantly from coronary patients not receiving beta-blockers. The results indicate that patients with coronary disease have a low melatonin production rate, with greater decreases in those with higher risk of cardiac infarction and/or death.

Authors+Show Affiliations

División Cardiología, Hospital Ramos Jejía, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11034110

Citation

Girotti, L, et al. "Low Urinary 6-sulphatoxymelatonin Levels in Patients With Coronary Artery Disease." Journal of Pineal Research, vol. 29, no. 3, 2000, pp. 138-42.
Girotti L, Lago M, Ianovsky O, et al. Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. J Pineal Res. 2000;29(3):138-42.
Girotti, L., Lago, M., Ianovsky, O., Carbajales, J., Elizari, M. V., Brusco, L. I., & Cardinali, D. P. (2000). Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. Journal of Pineal Research, 29(3), pp. 138-42.
Girotti L, et al. Low Urinary 6-sulphatoxymelatonin Levels in Patients With Coronary Artery Disease. J Pineal Res. 2000;29(3):138-42. PubMed PMID: 11034110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. AU - Girotti,L, AU - Lago,M, AU - Ianovsky,O, AU - Carbajales,J, AU - Elizari,M V, AU - Brusco,L I, AU - Cardinali,D P, PY - 2000/10/18/pubmed PY - 2001/2/28/medline PY - 2000/10/18/entrez SP - 138 EP - 42 JF - Journal of pineal research JO - J. Pineal Res. VL - 29 IS - 3 N2 - A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin concentration) in patients with chronic stable or unstable coronary disease and in a group of age-matched controls. Three groups of individuals were studied: a) 24 healthy subjects (mean age: 63 +/- 13 yr); b) 32 patients with chronic, stable, coronary disease (62 +/- 11 yr); and c) 27 patients with unstable angina (62 +/- 12 yr). For 6-sulphatoxymelatonin measurement, urine was collected from 18:00 to 06:00 hr, within 48 hr of hospitalization in the case of unstable angina. 6-Sulphatoxymelatonin was measured by a specific radioimmunoassay. Urinary 6-sulphatoxymelatonin excretion was significantly lower in unstable angina patients than in healthy subjects or in patients with stable angina. 6-Sulphatoxymelatonin correlated negatively with age in healthy subjects, but not in coronary patients. 6-Sulphatoxymelatonin excretion in patients treated with beta-adrenoceptor blockers did not differ significantly from coronary patients not receiving beta-blockers. The results indicate that patients with coronary disease have a low melatonin production rate, with greater decreases in those with higher risk of cardiac infarction and/or death. SN - 0742-3098 UR - https://www.unboundmedicine.com/medline/citation/11034110/Low_urinary_6_sulphatoxymelatonin_levels_in_patients_with_coronary_artery_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0742-3098&date=2000&volume=29&issue=3&spage=138 DB - PRIME DP - Unbound Medicine ER -