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Gastric emptying: a contributory factor in gastro-oesophageal reflux activity?
Gut 2000; 47(5):661-6Gut

Abstract

AIMS

To evaluate the impact of total and proximal stomach emptying on 24 hour and postprandial reflux as well as the number of reflux episodes per hour in relation to the impact of lower oesophageal sphincter (LOS) pressure, and oesophageal contractile and clearance function.

METHODS

Seventy one outpatients (37 female, 34 male; age 23-82 years) with symptoms suggestive of both delayed gastric emptying and reflux referred for further investigations participated in the study. Gastric emptying of a semisolid 1168 kJ meal and oesophageal clearance of a water bolus (supine) were recorded scintigraphically, reflux by 24 hour pH monitoring, and oesophageal motility manometrically.

RESULTS

Slow proximal but not slow distal or total stomach emptying correlated with increased 24 hour and postprandial acid exposure and increased number of reflux episodes/hour. No relationship was found between total or proximal emptying and LOS resting pressure, oesophageal contraction amplitude, percentage of failed contractions, or clearance. Multiple linear regression analyses showed that slow proximal emptying and low LOS pressure contributed significantly to both 24 hour (p=0.0007 and p=0. 0001) and two hour postprandial acid exposure (p=0.007 and p=0.0001). In contrast, the rate of total emptying contributed to neither 24 hour nor postprandial acid exposure.

CONCLUSION

Our data suggest that in contrast with total stomach emptying, the rate of proximal stomach emptying contributes to the extent of 24 hour as well as postprandial acid exposure and the number of reflux episodes/hour.

Authors+Show Affiliations

Psychophysiology Unit, Department of Surgery, University of Vienna, Vienna, Austria. georg.stacher@akh-wien@ac.at

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11034582

Citation

Stacher, G, et al. "Gastric Emptying: a Contributory Factor in Gastro-oesophageal Reflux Activity?" Gut, vol. 47, no. 5, 2000, pp. 661-6.
Stacher G, Lenglinger J, Bergmann H, et al. Gastric emptying: a contributory factor in gastro-oesophageal reflux activity? Gut. 2000;47(5):661-6.
Stacher, G., Lenglinger, J., Bergmann, H., Schneider, C., Hoffmann, M., Wölfl, G., & Stacher-Janotta, G. (2000). Gastric emptying: a contributory factor in gastro-oesophageal reflux activity? Gut, 47(5), pp. 661-6.
Stacher G, et al. Gastric Emptying: a Contributory Factor in Gastro-oesophageal Reflux Activity. Gut. 2000;47(5):661-6. PubMed PMID: 11034582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric emptying: a contributory factor in gastro-oesophageal reflux activity? AU - Stacher,G, AU - Lenglinger,J, AU - Bergmann,H, AU - Schneider,C, AU - Hoffmann,M, AU - Wölfl,G, AU - Stacher-Janotta,G, PY - 2000/10/18/pubmed PY - 2001/2/28/medline PY - 2000/10/18/entrez SP - 661 EP - 6 JF - Gut JO - Gut VL - 47 IS - 5 N2 - AIMS: To evaluate the impact of total and proximal stomach emptying on 24 hour and postprandial reflux as well as the number of reflux episodes per hour in relation to the impact of lower oesophageal sphincter (LOS) pressure, and oesophageal contractile and clearance function. METHODS: Seventy one outpatients (37 female, 34 male; age 23-82 years) with symptoms suggestive of both delayed gastric emptying and reflux referred for further investigations participated in the study. Gastric emptying of a semisolid 1168 kJ meal and oesophageal clearance of a water bolus (supine) were recorded scintigraphically, reflux by 24 hour pH monitoring, and oesophageal motility manometrically. RESULTS: Slow proximal but not slow distal or total stomach emptying correlated with increased 24 hour and postprandial acid exposure and increased number of reflux episodes/hour. No relationship was found between total or proximal emptying and LOS resting pressure, oesophageal contraction amplitude, percentage of failed contractions, or clearance. Multiple linear regression analyses showed that slow proximal emptying and low LOS pressure contributed significantly to both 24 hour (p=0.0007 and p=0. 0001) and two hour postprandial acid exposure (p=0.007 and p=0.0001). In contrast, the rate of total emptying contributed to neither 24 hour nor postprandial acid exposure. CONCLUSION: Our data suggest that in contrast with total stomach emptying, the rate of proximal stomach emptying contributes to the extent of 24 hour as well as postprandial acid exposure and the number of reflux episodes/hour. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/11034582/Gastric_emptying:_a_contributory_factor_in_gastro_oesophageal_reflux_activity L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=11034582 DB - PRIME DP - Unbound Medicine ER -