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The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome.
Arthritis Rheum. 2000 Oct; 43(10):2349-58.AR

Abstract

OBJECTIVE

To investigate the relationship between the 4G/5G polymorphism of the type 1 plasminogen activator inhibitor (PAI-1) gene and thrombotic manifestations in patients with antiphospholipid syndrome (APS).

METHODS

We studied a total of 247 patients included in the following 4 groups: 70 patients with primary APS, 104 patients with systemic lupus erythematosus (40 with antiphospholipid antibodies [aPL] and clinical [secondary] APS, 13 with aPL but without clinical APS, and 51 with neither detectable aPL nor a history of thrombosis), 14 asymptomatic individuals with aPL, and 59 patients with thrombosis but without known thrombosis risk factors. A control group of 100 healthy individuals was also analyzed. PAI-1 4G/5G polymorphism was determined by polymerase chain reaction and endonuclease digestion.

RESULTS

The allele frequency of 4G/5G in controls was 0.47/0.53. There were no differences in allele distribution among patient groups or between patients and controls. However, a higher frequency of the 4G allele was observed in APS patients with versus those without thrombosis (0.57 versus 0.39; P < 0.05) (odds ratio [OR] 2.83, 95% confidence interval [95% CI] 1.18-6.76). This higher frequency of the 4G allele was attributable to the higher frequency in patients with versus those without arterial thrombosis (0.64 versus 0.43; P < 0.01) (OR 5.96, 95% CI 1.67-21.32), while patients with venous thrombosis had an allele distribution similar to that of those without venous thrombosis (0.49 versus 0.50; P not significant). There was a trend toward higher PAI-1 antigen and activity levels in APS patients and controls with the 4G/4G genotype, but this did not reach statistical significance.

CONCLUSION

The presence of the 4G allele of the 4G/5G polymorphism of the PAI-1 gene may be an additional risk factor for the development of arterial thrombosis in APS.

Authors+Show Affiliations

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11037896

Citation

Tàssies, D, et al. "The 4G/5G Polymorphism of the Type 1 Plasminogen Activator Inhibitor Gene and Thrombosis in Patients With Antiphospholipid Syndrome." Arthritis and Rheumatism, vol. 43, no. 10, 2000, pp. 2349-58.
Tàssies D, Espinosa G, Muñoz-Rodríguez FJ, et al. The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome. Arthritis Rheum. 2000;43(10):2349-58.
Tàssies, D., Espinosa, G., Muñoz-Rodríguez, F. J., Freire, C., Cervera, R., Monteagudo, J., Maragall, S., Escolar, G., Ingelmo, M., Ordinas, A., Font, J., & Reverter, J. C. (2000). The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome. Arthritis and Rheumatism, 43(10), 2349-58.
Tàssies D, et al. The 4G/5G Polymorphism of the Type 1 Plasminogen Activator Inhibitor Gene and Thrombosis in Patients With Antiphospholipid Syndrome. Arthritis Rheum. 2000;43(10):2349-58. PubMed PMID: 11037896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome. AU - Tàssies,D, AU - Espinosa,G, AU - Muñoz-Rodríguez,F J, AU - Freire,C, AU - Cervera,R, AU - Monteagudo,J, AU - Maragall,S, AU - Escolar,G, AU - Ingelmo,M, AU - Ordinas,A, AU - Font,J, AU - Reverter,J C, PY - 2000/10/19/pubmed PY - 2001/2/28/medline PY - 2000/10/19/entrez SP - 2349 EP - 58 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 43 IS - 10 N2 - OBJECTIVE: To investigate the relationship between the 4G/5G polymorphism of the type 1 plasminogen activator inhibitor (PAI-1) gene and thrombotic manifestations in patients with antiphospholipid syndrome (APS). METHODS: We studied a total of 247 patients included in the following 4 groups: 70 patients with primary APS, 104 patients with systemic lupus erythematosus (40 with antiphospholipid antibodies [aPL] and clinical [secondary] APS, 13 with aPL but without clinical APS, and 51 with neither detectable aPL nor a history of thrombosis), 14 asymptomatic individuals with aPL, and 59 patients with thrombosis but without known thrombosis risk factors. A control group of 100 healthy individuals was also analyzed. PAI-1 4G/5G polymorphism was determined by polymerase chain reaction and endonuclease digestion. RESULTS: The allele frequency of 4G/5G in controls was 0.47/0.53. There were no differences in allele distribution among patient groups or between patients and controls. However, a higher frequency of the 4G allele was observed in APS patients with versus those without thrombosis (0.57 versus 0.39; P < 0.05) (odds ratio [OR] 2.83, 95% confidence interval [95% CI] 1.18-6.76). This higher frequency of the 4G allele was attributable to the higher frequency in patients with versus those without arterial thrombosis (0.64 versus 0.43; P < 0.01) (OR 5.96, 95% CI 1.67-21.32), while patients with venous thrombosis had an allele distribution similar to that of those without venous thrombosis (0.49 versus 0.50; P not significant). There was a trend toward higher PAI-1 antigen and activity levels in APS patients and controls with the 4G/4G genotype, but this did not reach statistical significance. CONCLUSION: The presence of the 4G allele of the 4G/5G polymorphism of the PAI-1 gene may be an additional risk factor for the development of arterial thrombosis in APS. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/11037896/The_4G/5G_polymorphism_of_the_type_1_plasminogen_activator_inhibitor_gene_and_thrombosis_in_patients_with_antiphospholipid_syndrome_ DB - PRIME DP - Unbound Medicine ER -