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Gallotannins inhibit growth, water-insoluble glucan synthesis, and aggregation of mutans streptococci.
J Dent Res 1988; 67(1):51-5JD

Abstract

During screening for anti-plaque agents of plant origin, ethanolic extracts from Melaphis chinensis (Bell), the Chinese Nutgall, exhibited strong inhibition of glucosyltransferase (GTF), in vitro adherence and glucan-induced agglutination of Streptococcus mutans 3209 and S. sobrinus B13. More than 91% inhibition of water-insoluble glucan synthesis from sucrose by GTF was noted at a concentration as low as 7.8 micrograms/mL. Bactericidal effects on other mutans streptococci, S. salivarius, and Actinomyces viscosus were also evident. Through chemical fractionation and analyses, along with bioassays, the active components were identified as gallotannins.

Authors+Show Affiliations

Department of Biological Sciences, Chicago State University, Illinois 60628, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11039045

Citation

Wu-Yuan, C D., et al. "Gallotannins Inhibit Growth, Water-insoluble Glucan Synthesis, and Aggregation of Mutans Streptococci." Journal of Dental Research, vol. 67, no. 1, 1988, pp. 51-5.
Wu-Yuan CD, Chen CY, Wu RT. Gallotannins inhibit growth, water-insoluble glucan synthesis, and aggregation of mutans streptococci. J Dent Res. 1988;67(1):51-5.
Wu-Yuan, C. D., Chen, C. Y., & Wu, R. T. (1988). Gallotannins inhibit growth, water-insoluble glucan synthesis, and aggregation of mutans streptococci. Journal of Dental Research, 67(1), pp. 51-5.
Wu-Yuan CD, Chen CY, Wu RT. Gallotannins Inhibit Growth, Water-insoluble Glucan Synthesis, and Aggregation of Mutans Streptococci. J Dent Res. 1988;67(1):51-5. PubMed PMID: 11039045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallotannins inhibit growth, water-insoluble glucan synthesis, and aggregation of mutans streptococci. AU - Wu-Yuan,C D, AU - Chen,C Y, AU - Wu,R T, PY - 1988/1/1/pubmed PY - 2001/2/28/medline PY - 1988/1/1/entrez SP - 51 EP - 5 JF - Journal of dental research JO - J. Dent. Res. VL - 67 IS - 1 N2 - During screening for anti-plaque agents of plant origin, ethanolic extracts from Melaphis chinensis (Bell), the Chinese Nutgall, exhibited strong inhibition of glucosyltransferase (GTF), in vitro adherence and glucan-induced agglutination of Streptococcus mutans 3209 and S. sobrinus B13. More than 91% inhibition of water-insoluble glucan synthesis from sucrose by GTF was noted at a concentration as low as 7.8 micrograms/mL. Bactericidal effects on other mutans streptococci, S. salivarius, and Actinomyces viscosus were also evident. Through chemical fractionation and analyses, along with bioassays, the active components were identified as gallotannins. SN - 0022-0345 UR - https://www.unboundmedicine.com/medline/citation/11039045/Gallotannins_inhibit_growth_water_insoluble_glucan_synthesis_and_aggregation_of_mutans_streptococci_ L2 - http://journals.sagepub.com/doi/full/10.1177/00220345880670011001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -