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Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory.
Learn Mem. 2000 Sep-Oct; 7(5):287-92.LM

Abstract

The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitory avoidance. There has been recent research into the effects of this drug in contextual fear conditioning and tone fear conditioning paradigms. The purpose of the present study was to assess the role of the selective M1 muscarinic antagonist dicyclomine in these paradigms and in the inhibitory avoidance test. Rats were administered different doses of dicyclomine or saline 30 min before acquisition training. The animals were tested 24 hr later, and it was observed that 16 mg/kg of dicyclomine impaired both contextual fear conditioning and inhibitory avoidance. However, dicyclomine (up to 64 mg/kg) did not affect tone fear conditioning. These results suggest that the selective M1 muscarinic antagonist dicyclomine differentially affects aversively motivated tasks known to be dependent on hippocampal integrity (such as contextual fear conditioning and inhibitory avoidance) but does not affect similar hippocampus-independent tasks.

Authors+Show Affiliations

Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 925 CEP 04024-002, São Paulo SP, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11040260

Citation

Fornari, R V., et al. "Effects of the Selective M1 Muscarinic Receptor Antagonist Dicyclomine On Emotional Memory." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 7, no. 5, 2000, pp. 287-92.
Fornari RV, Moreira KM, Oliveira MG. Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory. Learn Mem. 2000;7(5):287-92.
Fornari, R. V., Moreira, K. M., & Oliveira, M. G. (2000). Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory. Learning & Memory (Cold Spring Harbor, N.Y.), 7(5), 287-92.
Fornari RV, Moreira KM, Oliveira MG. Effects of the Selective M1 Muscarinic Receptor Antagonist Dicyclomine On Emotional Memory. Learn Mem. 2000 Sep-Oct;7(5):287-92. PubMed PMID: 11040260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory. AU - Fornari,R V, AU - Moreira,K M, AU - Oliveira,M G, PY - 2000/10/21/pubmed PY - 2001/2/28/medline PY - 2000/10/21/entrez SP - 287 EP - 92 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 7 IS - 5 N2 - The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitory avoidance. There has been recent research into the effects of this drug in contextual fear conditioning and tone fear conditioning paradigms. The purpose of the present study was to assess the role of the selective M1 muscarinic antagonist dicyclomine in these paradigms and in the inhibitory avoidance test. Rats were administered different doses of dicyclomine or saline 30 min before acquisition training. The animals were tested 24 hr later, and it was observed that 16 mg/kg of dicyclomine impaired both contextual fear conditioning and inhibitory avoidance. However, dicyclomine (up to 64 mg/kg) did not affect tone fear conditioning. These results suggest that the selective M1 muscarinic antagonist dicyclomine differentially affects aversively motivated tasks known to be dependent on hippocampal integrity (such as contextual fear conditioning and inhibitory avoidance) but does not affect similar hippocampus-independent tasks. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/11040260/Effects_of_the_selective_M1_muscarinic_receptor_antagonist_dicyclomine_on_emotional_memory_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/11040260/ DB - PRIME DP - Unbound Medicine ER -