Tags

Type your tag names separated by a space and hit enter

Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases.
J Anal Toxicol. 2000 Oct; 24(7):627-34.JA

Abstract

Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily absorbed through the skin and subsequently distributed throughout the body. Over the past three years, the Los Angeles County Coroner's Toxicology Laboratory has encountered 25 cases involving Duragesic patches (fentanyl), and their postmortem tissue distributions are presented here. The analysis of fentanyl from postmortem specimens (3-mL or g sample size) consisted of an n-butyl chloride basic extraction followed by identification and quantitation on a gas chromatograph-mass spectrometer using the selected ion monitoring (SIM) mode. The fentanyl ions monitored were m/z 245, 146, and 189 and the internal standard, fentanyl-d5 ions, were m/z 250, 151, and 194 (quantitation ion underlined). The linear range of the assay was 1.67 microg/L to 500 microg/L with the limit of quantitation and detection of 1.67 microg/L. The postmortem tissue distribution ranges of fentanyl in the 25 fatalities were as follows: heart blood, 1.8-139 microg/L (23 cases); femoral blood, 3.1-43 microg/L (13 cases); vitreous, +<2.0-20 microg/L (4 cases); liver, 5.8-613 microg/kg (22 cases); bile, 3.5-262 microg/L (15 cases); urine, 2.9-895 microg/L (19 cases); gastric, 0-1200 microg total (17 cases); spleen, 7.8-79 microg/kg (3 cases); kidney, 11 microg/kg (1 case); and lung, 31 microg/kg (1 case). The age of the decedents in this study ranged from 19 to 84, with an average age of 46. The modes of death included 15 accidental, 5 natural, 3 suicidal, and 2 undetermined. The main objectives of this paper are to show the prevalence of fentanyl patches in our community and to aid the forensic toxicologist with the interpretation of postmortem fentanyl levels in casework.

Authors+Show Affiliations

Los Angeles County Department of Coroner, Los Angeles, California 90033, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11043670

Citation

Anderson, D T., and J J. Muto. "Duragesic Transdermal Patch: Postmortem Tissue Distribution of Fentanyl in 25 Cases." Journal of Analytical Toxicology, vol. 24, no. 7, 2000, pp. 627-34.
Anderson DT, Muto JJ. Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. J Anal Toxicol. 2000;24(7):627-34.
Anderson, D. T., & Muto, J. J. (2000). Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. Journal of Analytical Toxicology, 24(7), 627-34.
Anderson DT, Muto JJ. Duragesic Transdermal Patch: Postmortem Tissue Distribution of Fentanyl in 25 Cases. J Anal Toxicol. 2000;24(7):627-34. PubMed PMID: 11043670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. AU - Anderson,D T, AU - Muto,J J, PY - 2000/10/24/pubmed PY - 2001/3/3/medline PY - 2000/10/24/entrez SP - 627 EP - 34 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 24 IS - 7 N2 - Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily absorbed through the skin and subsequently distributed throughout the body. Over the past three years, the Los Angeles County Coroner's Toxicology Laboratory has encountered 25 cases involving Duragesic patches (fentanyl), and their postmortem tissue distributions are presented here. The analysis of fentanyl from postmortem specimens (3-mL or g sample size) consisted of an n-butyl chloride basic extraction followed by identification and quantitation on a gas chromatograph-mass spectrometer using the selected ion monitoring (SIM) mode. The fentanyl ions monitored were m/z 245, 146, and 189 and the internal standard, fentanyl-d5 ions, were m/z 250, 151, and 194 (quantitation ion underlined). The linear range of the assay was 1.67 microg/L to 500 microg/L with the limit of quantitation and detection of 1.67 microg/L. The postmortem tissue distribution ranges of fentanyl in the 25 fatalities were as follows: heart blood, 1.8-139 microg/L (23 cases); femoral blood, 3.1-43 microg/L (13 cases); vitreous, +<2.0-20 microg/L (4 cases); liver, 5.8-613 microg/kg (22 cases); bile, 3.5-262 microg/L (15 cases); urine, 2.9-895 microg/L (19 cases); gastric, 0-1200 microg total (17 cases); spleen, 7.8-79 microg/kg (3 cases); kidney, 11 microg/kg (1 case); and lung, 31 microg/kg (1 case). The age of the decedents in this study ranged from 19 to 84, with an average age of 46. The modes of death included 15 accidental, 5 natural, 3 suicidal, and 2 undetermined. The main objectives of this paper are to show the prevalence of fentanyl patches in our community and to aid the forensic toxicologist with the interpretation of postmortem fentanyl levels in casework. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/11043670/Duragesic_transdermal_patch:_postmortem_tissue_distribution_of_fentanyl_in_25_cases_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/24.7.627 DB - PRIME DP - Unbound Medicine ER -