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The immune response to acute otitis media in children. II. Serum and middle ear fluid antibody in otitis media due to Haemophilus influenza.
J Infect Dis. 1975 Dec; 132(6):685-8.JI

Abstract

The antibody response in serum and middle ear fluid was studied in 40 children less than two years of age who had otitis media due to Haemophilus influenzae. Specific antibody in serum was determined by either a bacteriocidal test or an indirect fluorescent antibody test, and in the middle ear fluid by the latter test. For both assays the infecting bacterium of the patient was used. Half of the acute sera and three-fourths of the convalescent sera had antibody of at least one of the IgG, IgM, or IgA classes; IgG occurred most often. Fourteen patients had significant increases in specific antibody in the convalescent serum. Middle ear fluids from 22 to 29 patients had specific antibody. IgG and IgA antibodies occurred with equal frequency, but IgA antibody was found more often in middle ear fluids when IgA antibody was absent from serum. Thus it appears that infants with otitis media respond systemically and locally with specific antibody to H. influenzae.

Authors

Sloyer JL
No affiliation info available
Cate CC
No affiliation info available
Howie VM
No affiliation info available
Ploussard JH
No affiliation info available
Johnston RB
No affiliation info available

MeSH

Acute DiseaseAntibodies, BacterialAntibody FormationEar, MiddleFluorescent Antibody TechniqueHaemophilus InfectionsHaemophilus influenzaeHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MInfantOtitis Media

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1104722

Citation

Sloyer, J L., et al. "The Immune Response to Acute Otitis Media in Children. II. Serum and Middle Ear Fluid Antibody in Otitis Media Due to Haemophilus Influenza." The Journal of Infectious Diseases, vol. 132, no. 6, 1975, pp. 685-8.
Sloyer JL, Cate CC, Howie VM, et al. The immune response to acute otitis media in children. II. Serum and middle ear fluid antibody in otitis media due to Haemophilus influenza. J Infect Dis. 1975;132(6):685-8.
Sloyer, J. L., Cate, C. C., Howie, V. M., Ploussard, J. H., & Johnston, R. B. (1975). The immune response to acute otitis media in children. II. Serum and middle ear fluid antibody in otitis media due to Haemophilus influenza. The Journal of Infectious Diseases, 132(6), 685-8.
Sloyer JL, et al. The Immune Response to Acute Otitis Media in Children. II. Serum and Middle Ear Fluid Antibody in Otitis Media Due to Haemophilus Influenza. J Infect Dis. 1975;132(6):685-8. PubMed PMID: 1104722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immune response to acute otitis media in children. II. Serum and middle ear fluid antibody in otitis media due to Haemophilus influenza. AU - Sloyer,J L,Jr AU - Cate,C C, AU - Howie,V M, AU - Ploussard,J H, AU - Johnston,R B,Jr PY - 1975/12/11/pubmed PY - 2001/3/28/medline PY - 1975/12/11/entrez SP - 685 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 132 IS - 6 N2 - The antibody response in serum and middle ear fluid was studied in 40 children less than two years of age who had otitis media due to Haemophilus influenzae. Specific antibody in serum was determined by either a bacteriocidal test or an indirect fluorescent antibody test, and in the middle ear fluid by the latter test. For both assays the infecting bacterium of the patient was used. Half of the acute sera and three-fourths of the convalescent sera had antibody of at least one of the IgG, IgM, or IgA classes; IgG occurred most often. Fourteen patients had significant increases in specific antibody in the convalescent serum. Middle ear fluids from 22 to 29 patients had specific antibody. IgG and IgA antibodies occurred with equal frequency, but IgA antibody was found more often in middle ear fluids when IgA antibody was absent from serum. Thus it appears that infants with otitis media respond systemically and locally with specific antibody to H. influenzae. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/1104722/The_immune_response_to_acute_otitis_media_in_children__II__Serum_and_middle_ear_fluid_antibody_in_otitis_media_due_to_Haemophilus_influenza_ DB - PRIME DP - Unbound Medicine ER -