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[Implication of extracellular matrix metalloproteinases in the course of chronic inflammatory airway diseases].
Morphologie. 2000 Jun; 84(265):45-9.M

Abstract

Matrix metalloproteinases (MMPs) are major proteolytic enzymes that are involved in extracellular matrix (ECM) turn over. MMP-2 (gelatinase A) and MMP-9 (gelatinase B) cleave type IV collagen, which is an important constituent of basement membrane. These enzymes play an important role in normal tissue homeostasis, but imbalance between MMPs and their tissue inhibitors (TIMPs) is thought to be a critical factor in regulating tissue remodeling. MMP-2 is produced by fibroblasts, endothelial, and epithelial cells, while MMP-9 is mainly produced by inflammatory cells. The role of MMPs was investigated through biochemical analysis or in situ expression, in the pathogenesis of two chronic inflammatory airway diseases, asthma and nasal polyposis. Both are characterized with the accumulation of active inflammatory cells, matrix remodeling and epithelial changes. Increased levels of MMP-9 and TIMP-1 were found in asthmatic subjects and NP. In NP, MMP-9 expression was detected in epithelial, endothelial and inflammatory cells. In this setting, MMP-9 could play a crucial role in the transmigration of basement membrane components by inflammatory cells leading to inflammatory cell accumulation and maintenance of inflammation in airway. Moreover, MMP-9 may contribute to cell migration, an important mechanism involved in the repair of the respiratory epithelium.

Authors+Show Affiliations

Lechapt-Zalcman E
INSERM U492, Faculté de Médecine, Université Paris XII, France. emmanuele.lechapt@hmn.ap-hop-paris.fr
Escudier E
No affiliation info available

MeSH

AsthmaCell MovementEndothelium, VascularEpithelial CellsExtracellular MatrixExtracellular Matrix ProteinsFibroblastsHumansInflammationMatrix Metalloproteinase 2Matrix Metalloproteinase 9MetalloendopeptidasesNasal PolypsRespiratory Tract DiseasesTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

11048298

Citation

Lechapt-Zalcman, E, and E Escudier. "[Implication of Extracellular Matrix Metalloproteinases in the Course of Chronic Inflammatory Airway Diseases]." Morphologie : Bulletin De l'Association Des Anatomistes, vol. 84, no. 265, 2000, pp. 45-9.
Lechapt-Zalcman E, Escudier E. [Implication of extracellular matrix metalloproteinases in the course of chronic inflammatory airway diseases]. Morphologie. 2000;84(265):45-9.
Lechapt-Zalcman, E., & Escudier, E. (2000). [Implication of extracellular matrix metalloproteinases in the course of chronic inflammatory airway diseases]. Morphologie : Bulletin De l'Association Des Anatomistes, 84(265), 45-9.
Lechapt-Zalcman E, Escudier E. [Implication of Extracellular Matrix Metalloproteinases in the Course of Chronic Inflammatory Airway Diseases]. Morphologie. 2000;84(265):45-9. PubMed PMID: 11048298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Implication of extracellular matrix metalloproteinases in the course of chronic inflammatory airway diseases]. AU - Lechapt-Zalcman,E, AU - Escudier,E, PY - 2000/10/26/pubmed PY - 2001/2/28/medline PY - 2000/10/26/entrez SP - 45 EP - 9 JF - Morphologie : bulletin de l'Association des anatomistes JO - Morphologie VL - 84 IS - 265 N2 - Matrix metalloproteinases (MMPs) are major proteolytic enzymes that are involved in extracellular matrix (ECM) turn over. MMP-2 (gelatinase A) and MMP-9 (gelatinase B) cleave type IV collagen, which is an important constituent of basement membrane. These enzymes play an important role in normal tissue homeostasis, but imbalance between MMPs and their tissue inhibitors (TIMPs) is thought to be a critical factor in regulating tissue remodeling. MMP-2 is produced by fibroblasts, endothelial, and epithelial cells, while MMP-9 is mainly produced by inflammatory cells. The role of MMPs was investigated through biochemical analysis or in situ expression, in the pathogenesis of two chronic inflammatory airway diseases, asthma and nasal polyposis. Both are characterized with the accumulation of active inflammatory cells, matrix remodeling and epithelial changes. Increased levels of MMP-9 and TIMP-1 were found in asthmatic subjects and NP. In NP, MMP-9 expression was detected in epithelial, endothelial and inflammatory cells. In this setting, MMP-9 could play a crucial role in the transmigration of basement membrane components by inflammatory cells leading to inflammatory cell accumulation and maintenance of inflammation in airway. Moreover, MMP-9 may contribute to cell migration, an important mechanism involved in the repair of the respiratory epithelium. SN - 1286-0115 UR - https://www.unboundmedicine.com/medline/citation/11048298/[Implication_of_extracellular_matrix_metalloproteinases_in_the_course_of_chronic_inflammatory_airway_diseases]_ DB - PRIME DP - Unbound Medicine ER -