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Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities.
Biol Trace Elem Res 2000; 73(2):113-25BT

Abstract

Keshan disease is a cardiomyopathy restricted to the endemic areas of China and seen in residents having an extremely low selenium (Se) status. Prophylactic administration of sodium selenite has been shown to decrease significantly the incidence of acute and subacute cases. The aim offthe study was to assess the relative bioavailability of selenite versus organic Se-yeast in a Se-deficient area in China with a randomized double-blind double-dummy design. Healthy children (n=30) between 14 and 16 yr of age were randomized into three equal groups receiving either 200 microg/d selenite Se or 200 microg/d Se-yeast or placebo for 12 wk. Blood was drawn at baseline, 4, 8, and 12 wk and 4 wk postsupplementation. The plasma Se concentration (mean +/- SD) was 0.16+/-0.03 micromol/L at baseline. Selenite and Se-yeast supplementation increased plasma Se to plateau values, 1.0+/-0.2 and 1.3+/-0.2 micromol/L, respectively. In red cells, Se-yeast increased the selenium level sixfold and selenite threefold compared to placebo. The relative bioavailability of Se-yeast versus selenite measured as glutathione peroxidase (GSHPx) activity was similar in plasma, red blood cells, and platelets. GSHPx activity reached maximal levels in plasma and platelets of 300% and 200%, respectively, after 8 wk compared to the placebo group, but continued to increase in red cells for 16 wk. Our study showed that although both forms of Se were equally effective in raising GSHPx activity, Se-yeast provided a longer lasting body pool of Se. Se-yeast may be a better alternative to selenite in the prophylaxis of Keshan disease with respect to building up of body stores.

Authors+Show Affiliations

Department of Nutrition, National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11049204

Citation

Alfthan, G, et al. "Selenium Supplementation of Children in a Selenium-deficient Area in China: Blood Selenium Levels and Glutathione Peroxidase Activities." Biological Trace Element Research, vol. 73, no. 2, 2000, pp. 113-25.
Alfthan G, Xu GL, Tan WH, et al. Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. Biol Trace Elem Res. 2000;73(2):113-25.
Alfthan, G., Xu, G. L., Tan, W. H., Aro, A., Wu, J., Yang, Y. X., ... Kong, L. H. (2000). Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. Biological Trace Element Research, 73(2), pp. 113-25.
Alfthan G, et al. Selenium Supplementation of Children in a Selenium-deficient Area in China: Blood Selenium Levels and Glutathione Peroxidase Activities. Biol Trace Elem Res. 2000;73(2):113-25. PubMed PMID: 11049204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. AU - Alfthan,G, AU - Xu,G L, AU - Tan,W H, AU - Aro,A, AU - Wu,J, AU - Yang,Y X, AU - Liang,W S, AU - Xue,W L, AU - Kong,L H, PY - 1999/04/12/received PY - 1999/05/11/accepted PY - 2000/10/26/pubmed PY - 2001/2/28/medline PY - 2000/10/26/entrez SP - 113 EP - 25 JF - Biological trace element research JO - Biol Trace Elem Res VL - 73 IS - 2 N2 - Keshan disease is a cardiomyopathy restricted to the endemic areas of China and seen in residents having an extremely low selenium (Se) status. Prophylactic administration of sodium selenite has been shown to decrease significantly the incidence of acute and subacute cases. The aim offthe study was to assess the relative bioavailability of selenite versus organic Se-yeast in a Se-deficient area in China with a randomized double-blind double-dummy design. Healthy children (n=30) between 14 and 16 yr of age were randomized into three equal groups receiving either 200 microg/d selenite Se or 200 microg/d Se-yeast or placebo for 12 wk. Blood was drawn at baseline, 4, 8, and 12 wk and 4 wk postsupplementation. The plasma Se concentration (mean +/- SD) was 0.16+/-0.03 micromol/L at baseline. Selenite and Se-yeast supplementation increased plasma Se to plateau values, 1.0+/-0.2 and 1.3+/-0.2 micromol/L, respectively. In red cells, Se-yeast increased the selenium level sixfold and selenite threefold compared to placebo. The relative bioavailability of Se-yeast versus selenite measured as glutathione peroxidase (GSHPx) activity was similar in plasma, red blood cells, and platelets. GSHPx activity reached maximal levels in plasma and platelets of 300% and 200%, respectively, after 8 wk compared to the placebo group, but continued to increase in red cells for 16 wk. Our study showed that although both forms of Se were equally effective in raising GSHPx activity, Se-yeast provided a longer lasting body pool of Se. Se-yeast may be a better alternative to selenite in the prophylaxis of Keshan disease with respect to building up of body stores. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/11049204/Selenium_supplementation_of_children_in_a_selenium_deficient_area_in_China:_blood_selenium_levels_and_glutathione_peroxidase_activities_ L2 - https://dx.doi.org/10.1385/BTER:73:2:113 DB - PRIME DP - Unbound Medicine ER -