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Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study.
Brain. 2000 Nov; 123 (Pt 11):2297-305.B

Abstract

We investigated the prevalence of dyskinesias and motor fluctuations, and the factors determining their occurrence, in a community-based population of patients with Parkinson's disease. Among 124 patients with Parkinson's disease, 87 (70%) had received a levodopa preparation. Among these 87 patients, 28% were experiencing treatment-induced dyskinesias and 40% response fluctuations. The prevalence of motor fluctuations was best predicted by disease duration and dose of levodopa, whereas dyskinesias could be best predicted by duration of treatment. Patients with a shorter time from symptom onset to initiation of levodopa and younger patients had developed motor complications earlier, and patients who had started treatment with a dopamine agonist had developed these treatment complications later. Although a satisfactory response to medication was associated with higher rates of motor complications, poor or moderate response was associated with lower quality of life in patients with a disease duration of </=5 years or >/=10 years. We conclude that motor fluctuations are most strongly related to disease duration and dose of levodopa, and dyskinesias to duration of levodopa treatment. However, poorer quality of life associated with inadequate dosage of levodopa may be the price for a low rate of motor complications in patients with Parkinson's disease.

Authors+Show Affiliations

Department of Clinical Neurology, Institute of Neurology, London, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11050029

Citation

Schrag, A, and N Quinn. "Dyskinesias and Motor Fluctuations in Parkinson's Disease. a Community-based Study." Brain : a Journal of Neurology, vol. 123 (Pt 11), 2000, pp. 2297-305.
Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain. 2000;123 (Pt 11):2297-305.
Schrag, A., & Quinn, N. (2000). Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain : a Journal of Neurology, 123 (Pt 11), 2297-305.
Schrag A, Quinn N. Dyskinesias and Motor Fluctuations in Parkinson's Disease. a Community-based Study. Brain. 2000;123 (Pt 11):2297-305. PubMed PMID: 11050029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. AU - Schrag,A, AU - Quinn,N, PY - 2000/10/26/pubmed PY - 2001/2/28/medline PY - 2000/10/26/entrez SP - 2297 EP - 305 JF - Brain : a journal of neurology JO - Brain VL - 123 (Pt 11) N2 - We investigated the prevalence of dyskinesias and motor fluctuations, and the factors determining their occurrence, in a community-based population of patients with Parkinson's disease. Among 124 patients with Parkinson's disease, 87 (70%) had received a levodopa preparation. Among these 87 patients, 28% were experiencing treatment-induced dyskinesias and 40% response fluctuations. The prevalence of motor fluctuations was best predicted by disease duration and dose of levodopa, whereas dyskinesias could be best predicted by duration of treatment. Patients with a shorter time from symptom onset to initiation of levodopa and younger patients had developed motor complications earlier, and patients who had started treatment with a dopamine agonist had developed these treatment complications later. Although a satisfactory response to medication was associated with higher rates of motor complications, poor or moderate response was associated with lower quality of life in patients with a disease duration of </=5 years or >/=10 years. We conclude that motor fluctuations are most strongly related to disease duration and dose of levodopa, and dyskinesias to duration of levodopa treatment. However, poorer quality of life associated with inadequate dosage of levodopa may be the price for a low rate of motor complications in patients with Parkinson's disease. SN - 0006-8950 UR - https://www.unboundmedicine.com/medline/citation/11050029/Dyskinesias_and_motor_fluctuations_in_Parkinson's_disease__A_community_based_study_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/123.11.2297 DB - PRIME DP - Unbound Medicine ER -