Tags

Type your tag names separated by a space and hit enter

Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia.
J Am Acad Dermatol. 2000 Nov; 43(5 Pt 1):768-76.JA

Abstract

BACKGROUND

Finasteride, an inhibitor of type 2 5alpha-reductase, decreases serum and scalp dihydrotestosterone (DHT) by inhibiting conversion of testosterone to DHT and has been shown to be effective in men with androgenetic alopecia (AGA). The effects of finasteride in women with AGA have not been evaluated.

OBJECTIVE

The purpose of this study was to evaluate the efficacy of finasteride in postmenopausal women with AGA.

METHODS

In this 1-year, double-blind, placebo-controlled, randomized, multicenter trial, 137 postmenopausal women (41-60 years of age) with AGA received finasteride 1 mg/day or placebo. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, assessment of global photographs by a blinded expert panel, and histologic analysis of scalp biopsy specimens.

RESULTS

After 1 year of therapy, there was no significant difference in the change in hair count between the finasteride and placebo groups. Both treatment groups had significant decreases in hair count in the frontal/parietal (anterior/mid) scalp during the 1-year study period. Similarly, patient, investigator, and photographic assessments as well as scalp biopsy analysis did not demonstrate any improvement in slowing hair thinning, increasing hair growth, or improving the appearance of the hair in finasteride-treated subjects compared with the placebo group. Finasteride was generally well tolerated.

CONCLUSION

In postmenopausal women with AGA, finasteride 1 mg/day taken for 12 months did not not increase hair growth or slow the progression of hair thinning.

Authors+Show Affiliations

Price VH
University of California, San Francisco, USA.
Roberts JL
No affiliation info available
Hordinsky M
No affiliation info available
Olsen EA
No affiliation info available
Savin R
No affiliation info available
Bergfeld W
No affiliation info available
Fiedler V
No affiliation info available
Lucky A
No affiliation info available
Whiting DA
No affiliation info available
Pappas F
No affiliation info available
Culbertson J
No affiliation info available
Kotey P
No affiliation info available
Meehan A
No affiliation info available
Waldstreicher J
No affiliation info available

MeSH

Administration, OralAdultAlopeciaBiopsyDisease ProgressionDouble-Blind MethodEnzyme InhibitorsFemaleFinasterideHumansMiddle AgedPostmenopauseScalpTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11050579

Citation

Price, V H., et al. "Lack of Efficacy of Finasteride in Postmenopausal Women With Androgenetic Alopecia." Journal of the American Academy of Dermatology, vol. 43, no. 5 Pt 1, 2000, pp. 768-76.
Price VH, Roberts JL, Hordinsky M, et al. Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol. 2000;43(5 Pt 1):768-76.
Price, V. H., Roberts, J. L., Hordinsky, M., Olsen, E. A., Savin, R., Bergfeld, W., Fiedler, V., Lucky, A., Whiting, D. A., Pappas, F., Culbertson, J., Kotey, P., Meehan, A., & Waldstreicher, J. (2000). Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. Journal of the American Academy of Dermatology, 43(5 Pt 1), 768-76.
Price VH, et al. Lack of Efficacy of Finasteride in Postmenopausal Women With Androgenetic Alopecia. J Am Acad Dermatol. 2000;43(5 Pt 1):768-76. PubMed PMID: 11050579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. AU - Price,V H, AU - Roberts,J L, AU - Hordinsky,M, AU - Olsen,E A, AU - Savin,R, AU - Bergfeld,W, AU - Fiedler,V, AU - Lucky,A, AU - Whiting,D A, AU - Pappas,F, AU - Culbertson,J, AU - Kotey,P, AU - Meehan,A, AU - Waldstreicher,J, PY - 2000/10/26/pubmed PY - 2001/4/6/medline PY - 2000/10/26/entrez SP - 768 EP - 76 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 43 IS - 5 Pt 1 N2 - BACKGROUND: Finasteride, an inhibitor of type 2 5alpha-reductase, decreases serum and scalp dihydrotestosterone (DHT) by inhibiting conversion of testosterone to DHT and has been shown to be effective in men with androgenetic alopecia (AGA). The effects of finasteride in women with AGA have not been evaluated. OBJECTIVE: The purpose of this study was to evaluate the efficacy of finasteride in postmenopausal women with AGA. METHODS: In this 1-year, double-blind, placebo-controlled, randomized, multicenter trial, 137 postmenopausal women (41-60 years of age) with AGA received finasteride 1 mg/day or placebo. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, assessment of global photographs by a blinded expert panel, and histologic analysis of scalp biopsy specimens. RESULTS: After 1 year of therapy, there was no significant difference in the change in hair count between the finasteride and placebo groups. Both treatment groups had significant decreases in hair count in the frontal/parietal (anterior/mid) scalp during the 1-year study period. Similarly, patient, investigator, and photographic assessments as well as scalp biopsy analysis did not demonstrate any improvement in slowing hair thinning, increasing hair growth, or improving the appearance of the hair in finasteride-treated subjects compared with the placebo group. Finasteride was generally well tolerated. CONCLUSION: In postmenopausal women with AGA, finasteride 1 mg/day taken for 12 months did not not increase hair growth or slow the progression of hair thinning. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/11050579/Lack_of_efficacy_of_finasteride_in_postmenopausal_women_with_androgenetic_alopecia_ DB - PRIME DP - Unbound Medicine ER -