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Autonomic regulation of cardiac function during sleep in patients with irritable bowel syndrome.
Am J Gastroenterol. 2000 Oct; 95(10):2865-71.AJ

Abstract

OBJECTIVE

Several studies have provided evidence of abnormal autonomic activity in irritable bowel syndrome (IBS), suggesting that abnormal central nervous system-autonomic nervous system arousal mechanisms may be part of its pathophysiology. The goal was to investigate cardiac sympatho-vagal balance during waking and the different stages of sleep using heart rate variability analysis in IBS patients compared to healthy controls.

METHODS

A total of 15 IBS patients (13 female, two male, mean age 34.9 +/- 2.1 yr) and 15 controls (13 female, two male, mean age 36.2 +/- 2.3 yr) were studied during 1 h of pre-sleep quiet waking and during seven-hours of sleep. Polysomnography was used for the determination of state of consciousness. Electrocardiography provided the beat-to-beat intervals, which were then subjected to spectral analysis for determination of the percentage of energy in the low and high frequency bands, respectively. The low frequency/high frequency band ratio was also calculated. For each subject, heart rate variability analysis was performed using 15-min segments of waking, non-rapid eye movement sleep, and rapid eye movement sleep.

RESULTS

The low frequency band power was significantly greater in IBS patients during waking. No group differences were found in high frequency band power during any state. The low frequency to high frequency band ratio was significantly greater in IBS patients during rapid eye movement sleep.

CONCLUSIONS

IBS patients have greater sympathetic activity during waking and greater overall sympathetic dominance during rapid eye movement sleep. These results support the presence of autonomic abnormalities in patients with IBS. The possibility is discussed that sympathetic dominance during rapid eye movement sleep may play a role in sensitizing the gut to waking stimulation.

Authors+Show Affiliations

Lynn Institute for Healthcare Research, Oklahoma City, Oklahoma 73112, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11051361

Citation

Orr, W C., et al. "Autonomic Regulation of Cardiac Function During Sleep in Patients With Irritable Bowel Syndrome." The American Journal of Gastroenterology, vol. 95, no. 10, 2000, pp. 2865-71.
Orr WC, Elsenbruch S, Harnish MJ. Autonomic regulation of cardiac function during sleep in patients with irritable bowel syndrome. Am J Gastroenterol. 2000;95(10):2865-71.
Orr, W. C., Elsenbruch, S., & Harnish, M. J. (2000). Autonomic regulation of cardiac function during sleep in patients with irritable bowel syndrome. The American Journal of Gastroenterology, 95(10), 2865-71.
Orr WC, Elsenbruch S, Harnish MJ. Autonomic Regulation of Cardiac Function During Sleep in Patients With Irritable Bowel Syndrome. Am J Gastroenterol. 2000;95(10):2865-71. PubMed PMID: 11051361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic regulation of cardiac function during sleep in patients with irritable bowel syndrome. AU - Orr,W C, AU - Elsenbruch,S, AU - Harnish,M J, PY - 2000/10/29/pubmed PY - 2001/2/28/medline PY - 2000/10/29/entrez SP - 2865 EP - 71 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 10 N2 - OBJECTIVE: Several studies have provided evidence of abnormal autonomic activity in irritable bowel syndrome (IBS), suggesting that abnormal central nervous system-autonomic nervous system arousal mechanisms may be part of its pathophysiology. The goal was to investigate cardiac sympatho-vagal balance during waking and the different stages of sleep using heart rate variability analysis in IBS patients compared to healthy controls. METHODS: A total of 15 IBS patients (13 female, two male, mean age 34.9 +/- 2.1 yr) and 15 controls (13 female, two male, mean age 36.2 +/- 2.3 yr) were studied during 1 h of pre-sleep quiet waking and during seven-hours of sleep. Polysomnography was used for the determination of state of consciousness. Electrocardiography provided the beat-to-beat intervals, which were then subjected to spectral analysis for determination of the percentage of energy in the low and high frequency bands, respectively. The low frequency/high frequency band ratio was also calculated. For each subject, heart rate variability analysis was performed using 15-min segments of waking, non-rapid eye movement sleep, and rapid eye movement sleep. RESULTS: The low frequency band power was significantly greater in IBS patients during waking. No group differences were found in high frequency band power during any state. The low frequency to high frequency band ratio was significantly greater in IBS patients during rapid eye movement sleep. CONCLUSIONS: IBS patients have greater sympathetic activity during waking and greater overall sympathetic dominance during rapid eye movement sleep. These results support the presence of autonomic abnormalities in patients with IBS. The possibility is discussed that sympathetic dominance during rapid eye movement sleep may play a role in sensitizing the gut to waking stimulation. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11051361/Autonomic_regulation_of_cardiac_function_during_sleep_in_patients_with_irritable_bowel_syndrome_ DB - PRIME DP - Unbound Medicine ER -