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Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease.
Folia Biol (Praha) 2000; 46(5):181-5FB

Abstract

Genetic and environmental factors regulate lipid metabolism and phenotypic expression of CAD. In this study we assessed the effects of apoE gene polymorphism and apoA1 gene promoter polymorphism on lipid metabolism and risk for CAD. In a case-control study, 166 patients with CAD were compared with 130 healthy subjects. The apoE allele frequencies of patients vs. control group were 6.3% vs. 7.7% for e2, 84.3% vs. 84.6% for e3, and 9.4% vs. 7.7% for e4. Individuals with e3e4 and e4e4 genotypes had higher total (P = 0.023) and LDL cholesterol levels (P = 0.04) than individuals with other genotypes. There were no differences in lipid parameters between the subjects with the apoA1-GG genotype and subjects with AG or AA genotypes. However, univariate analysis revealed no association between risk genotypes (e3e4 and e4e4 genotypes) of apoE and CAD risk (OR = 1.1; 95% CI = 0.6-2.1, P = 0.8) as well as no association between the GG genotype and CAD risk (OR 0.7; 95% CI = 0.5-1.2, P = 0.19). No evidence for a synergistic interaction between e3e4 plus e4e4 genotypes and apoA1-GG genotype on CAD risk was found (OR = 1.3, 95% CI = 0.6-2.9; P = 0.5). One individual with familial defective apolipoprotein B-100 (Arg3500Gln) was found in each group. In conclusion, the apoE gene polymorphism affected the total and LDL cholesterol levels, whereas neither the apoE gene polymorphism nor the apoA-1 gene promoter polymorphism were shown to be independent risk factors for CAD in Slovenia.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Medical Center Ljubljana, Institute of Histology and Embryology, Slovenia. daniel.petrovic@mf.uni-lj.siNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11055796

Citation

Petrovic, D, et al. "Effect of Apolipoprotein E Polymorphism and Apolipoprotein A-1 Gene Promoter Polymorphism On Lipid Parameters and Premature Coronary Artery Disease." Folia Biologica, vol. 46, no. 5, 2000, pp. 181-5.
Petrovic D, Zorc M, Peterlin B. Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease. Folia Biol (Praha). 2000;46(5):181-5.
Petrovic, D., Zorc, M., & Peterlin, B. (2000). Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease. Folia Biologica, 46(5), pp. 181-5.
Petrovic D, Zorc M, Peterlin B. Effect of Apolipoprotein E Polymorphism and Apolipoprotein A-1 Gene Promoter Polymorphism On Lipid Parameters and Premature Coronary Artery Disease. Folia Biol (Praha). 2000;46(5):181-5. PubMed PMID: 11055796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease. AU - Petrovic,D, AU - Zorc,M, AU - Peterlin,B, PY - 2000/10/31/pubmed PY - 2001/3/3/medline PY - 2000/10/31/entrez SP - 181 EP - 5 JF - Folia biologica JO - Folia Biol. (Praha) VL - 46 IS - 5 N2 - Genetic and environmental factors regulate lipid metabolism and phenotypic expression of CAD. In this study we assessed the effects of apoE gene polymorphism and apoA1 gene promoter polymorphism on lipid metabolism and risk for CAD. In a case-control study, 166 patients with CAD were compared with 130 healthy subjects. The apoE allele frequencies of patients vs. control group were 6.3% vs. 7.7% for e2, 84.3% vs. 84.6% for e3, and 9.4% vs. 7.7% for e4. Individuals with e3e4 and e4e4 genotypes had higher total (P = 0.023) and LDL cholesterol levels (P = 0.04) than individuals with other genotypes. There were no differences in lipid parameters between the subjects with the apoA1-GG genotype and subjects with AG or AA genotypes. However, univariate analysis revealed no association between risk genotypes (e3e4 and e4e4 genotypes) of apoE and CAD risk (OR = 1.1; 95% CI = 0.6-2.1, P = 0.8) as well as no association between the GG genotype and CAD risk (OR 0.7; 95% CI = 0.5-1.2, P = 0.19). No evidence for a synergistic interaction between e3e4 plus e4e4 genotypes and apoA1-GG genotype on CAD risk was found (OR = 1.3, 95% CI = 0.6-2.9; P = 0.5). One individual with familial defective apolipoprotein B-100 (Arg3500Gln) was found in each group. In conclusion, the apoE gene polymorphism affected the total and LDL cholesterol levels, whereas neither the apoE gene polymorphism nor the apoA-1 gene promoter polymorphism were shown to be independent risk factors for CAD in Slovenia. SN - 0015-5500 UR - https://www.unboundmedicine.com/medline/citation/11055796/Effect_of_apolipoprotein_E_polymorphism_and_apolipoprotein_A_1_gene_promoter_polymorphism_on_lipid_parameters_and_premature_coronary_artery_disease_ DB - PRIME DP - Unbound Medicine ER -