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The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong.
Ann Acad Med Singapore 2000; 29(4):474-85AA

Abstract

INTRODUCTION

The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) was reported to be a sensitive cognitive function assessment scale for Alzheimer's Disease (AD). The English, Greek, Spanish but not Chinese versions had been validated previously.

OBJECTIVES

The objectives of the present study were to investigate the reliability and validity of an adapted Chinese version of the ADAS-cog among Chinese elderly AD patients in Hong Kong.

MATERIALS AND METHOD

Thirty-nine subjects were recruited during the period July to December 1998. Twenty were AD patients while 19 were non-demented normal subjects. Two raters administered the ADAS-cog scale thrice on different occasions.

RESULTS

The internal consistency (Cronbach's alpha) of the ADAS-cog were 0.91, 0.88 and 0.65 for the whole group, the AD and normal (i.e. non-demented) subjects respectively. The test-retest reliability as measured by the Spearman's rho correlation coefficients were 0.96, 0.86 and 0.86 for the whole group, AD and normal subjects, respectively, (all P < 0.001). The Spearman's rho correlation coefficients for inter-rater reliability were 0.95 (P < 0.001), 0.91 (P < 0.001) and 0.65 (P = 0.003) for the whole group, AD and normal subjects, respectively. The ADAS-cog score was inversely related to the Mini-Mental Status Examination (MMSE) score (Spearman's rho = -0.91; P < 0.001). The ADAS-cog score was directly proportional to the Clinical Dementia Rating (CDR) (rho = 0.89; P < 0.001). Forward stepwise discriminant function analysis between AD and normal subjects yielded a canonical discriminant function with 3-question items (i.e. word recall test, orientation and comprehension of speech; P < 0.001). This short version had a sensitivity of 90%, specificity of 94.7% and overall accuracy of 92.3%.

CONCLUSION

The Chinese version of ADAS-cog subscale is both reliable and valid among the elderly Chinese in Hong Kong.

Authors+Show Affiliations

Division of Geriatrics, University Department of Medicine, Queen Mary Hospital, Hong Kong SAR. lwchu@hkucc.hku.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

11056778

Citation

Chu, L W., et al. "The Reliability and Validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) Among the Elderly Chinese in Hong Kong." Annals of the Academy of Medicine, Singapore, vol. 29, no. 4, 2000, pp. 474-85.
Chu LW, Chiu KC, Hui SL, et al. The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong. Ann Acad Med Singap. 2000;29(4):474-85.
Chu, L. W., Chiu, K. C., Hui, S. L., Yu, G. K., Tsui, W. J., & Lee, P. W. (2000). The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong. Annals of the Academy of Medicine, Singapore, 29(4), pp. 474-85.
Chu LW, et al. The Reliability and Validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) Among the Elderly Chinese in Hong Kong. Ann Acad Med Singap. 2000;29(4):474-85. PubMed PMID: 11056778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong. AU - Chu,L W, AU - Chiu,K C, AU - Hui,S L, AU - Yu,G K, AU - Tsui,W J, AU - Lee,P W, PY - 2000/11/1/pubmed PY - 2001/3/3/medline PY - 2000/11/1/entrez SP - 474 EP - 85 JF - Annals of the Academy of Medicine, Singapore JO - Ann. Acad. Med. Singap. VL - 29 IS - 4 N2 - INTRODUCTION: The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) was reported to be a sensitive cognitive function assessment scale for Alzheimer's Disease (AD). The English, Greek, Spanish but not Chinese versions had been validated previously. OBJECTIVES: The objectives of the present study were to investigate the reliability and validity of an adapted Chinese version of the ADAS-cog among Chinese elderly AD patients in Hong Kong. MATERIALS AND METHOD: Thirty-nine subjects were recruited during the period July to December 1998. Twenty were AD patients while 19 were non-demented normal subjects. Two raters administered the ADAS-cog scale thrice on different occasions. RESULTS: The internal consistency (Cronbach's alpha) of the ADAS-cog were 0.91, 0.88 and 0.65 for the whole group, the AD and normal (i.e. non-demented) subjects respectively. The test-retest reliability as measured by the Spearman's rho correlation coefficients were 0.96, 0.86 and 0.86 for the whole group, AD and normal subjects, respectively, (all P < 0.001). The Spearman's rho correlation coefficients for inter-rater reliability were 0.95 (P < 0.001), 0.91 (P < 0.001) and 0.65 (P = 0.003) for the whole group, AD and normal subjects, respectively. The ADAS-cog score was inversely related to the Mini-Mental Status Examination (MMSE) score (Spearman's rho = -0.91; P < 0.001). The ADAS-cog score was directly proportional to the Clinical Dementia Rating (CDR) (rho = 0.89; P < 0.001). Forward stepwise discriminant function analysis between AD and normal subjects yielded a canonical discriminant function with 3-question items (i.e. word recall test, orientation and comprehension of speech; P < 0.001). This short version had a sensitivity of 90%, specificity of 94.7% and overall accuracy of 92.3%. CONCLUSION: The Chinese version of ADAS-cog subscale is both reliable and valid among the elderly Chinese in Hong Kong. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/11056778/The_reliability_and_validity_of_the_Alzheimer's_Disease_Assessment_Scale_Cognitive_Subscale__ADAS_Cog__among_the_elderly_Chinese_in_Hong_Kong_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -