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[Family study of patients with aspirin intolerance and rhinosinusitis].
HNO. 2000 Sep; 48(9):650-4.HNO

Abstract

The high prevalence of aspirin intolerance in asthmatics and patients with nasal polyps as well as reports of familial clustering suggest a genetic disposition of this disease. Our study aimed at obtaining further evidence of hereditary factors in this disease. We included 33 unselected patients from 28 families with aspirin intolerance and rhinosinusitis in this study. Controls were recruited from individuals treated in our ENT clinic for diseases other than aspirin intolerance (n = 52). A questionnaire focused on family histories as well as reports on diseases of the upper respiratory tract or allergies. ASS intolerance was verified either by bronchial or nasal provocation tests. We found cases of aspirin intolerance among parents, siblings, and children of ASS intolerant probands. The children of probands had nasal polyps and rhinosinusitis more often than the children of controls. We propose that ASS intolerance with nasal polyps and asthma represents a complex phenotype, with genetic and environmental factors contributing to its manifestation.

Authors+Show Affiliations

May A
Hals-Nasen-Ohren-Klinik, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Wagner D
No affiliation info available
Langenbeck U
No affiliation info available
Weber A
No affiliation info available

MeSH

AdolescentAdultAnti-Inflammatory Agents, Non-SteroidalAspirinAsthmaBronchial Provocation TestsChildChild, PreschoolDrug HypersensitivityFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedNasal PolypsNasal Provocation TestsPhenotypeRespiratory HypersensitivityRhinitisSinusitis

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

11056852

Citation

May, A, et al. "[Family Study of Patients With Aspirin Intolerance and Rhinosinusitis]." HNO, vol. 48, no. 9, 2000, pp. 650-4.
May A, Wagner D, Langenbeck U, et al. [Family study of patients with aspirin intolerance and rhinosinusitis]. HNO. 2000;48(9):650-4.
May, A., Wagner, D., Langenbeck, U., & Weber, A. (2000). [Family study of patients with aspirin intolerance and rhinosinusitis]. HNO, 48(9), 650-4.
May A, et al. [Family Study of Patients With Aspirin Intolerance and Rhinosinusitis]. HNO. 2000;48(9):650-4. PubMed PMID: 11056852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Family study of patients with aspirin intolerance and rhinosinusitis]. AU - May,A, AU - Wagner,D, AU - Langenbeck,U, AU - Weber,A, PY - 2000/11/1/pubmed PY - 2001/2/28/medline PY - 2000/11/1/entrez SP - 650 EP - 4 JF - HNO JO - HNO VL - 48 IS - 9 N2 - The high prevalence of aspirin intolerance in asthmatics and patients with nasal polyps as well as reports of familial clustering suggest a genetic disposition of this disease. Our study aimed at obtaining further evidence of hereditary factors in this disease. We included 33 unselected patients from 28 families with aspirin intolerance and rhinosinusitis in this study. Controls were recruited from individuals treated in our ENT clinic for diseases other than aspirin intolerance (n = 52). A questionnaire focused on family histories as well as reports on diseases of the upper respiratory tract or allergies. ASS intolerance was verified either by bronchial or nasal provocation tests. We found cases of aspirin intolerance among parents, siblings, and children of ASS intolerant probands. The children of probands had nasal polyps and rhinosinusitis more often than the children of controls. We propose that ASS intolerance with nasal polyps and asthma represents a complex phenotype, with genetic and environmental factors contributing to its manifestation. SN - 0017-6192 UR - https://www.unboundmedicine.com/medline/citation/11056852/[Family_study_of_patients_with_aspirin_intolerance_and_rhinosinusitis]_ DB - PRIME DP - Unbound Medicine ER -