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Genetic syndromes and genetic tests in colorectal cancer.
Semin Gastrointest Dis. 2000 Oct; 11(4):207-18.SG

Abstract

Our understanding of the biology of colon cancer has matured to the point that it is a useful general paradigm for understanding solid tumor development. Recent advances provide insight into the genetic alterations underlying the development of colon cancer. These insights provide unique opportunities for genetic testing in predisposed, asymptomatic patients that can direct screening efforts and their clinical management. This review examines several inherited colon cancer predispositions, well described clinically for a century, that are now amenable to genetic testing. Additional discussion focuses on colon cancer predisposition traits that occur with high frequency but low penetrance characteristics. Finally, genetic tests for tumor markers that potentially have prognostic or therapeutic implications are reviewed.

Authors+Show Affiliations

Department of Surgery, University of Virginia Health Systems, Charlottesville 22908-0708, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11057948

Citation

Calland, J F., et al. "Genetic Syndromes and Genetic Tests in Colorectal Cancer." Seminars in Gastrointestinal Disease, vol. 11, no. 4, 2000, pp. 207-18.
Calland JF, Adams RB, DePrince K, et al. Genetic syndromes and genetic tests in colorectal cancer. Semin Gastrointest Dis. 2000;11(4):207-18.
Calland, J. F., Adams, R. B., DePrince, K., Foley, E. F., & Powell, S. M. (2000). Genetic syndromes and genetic tests in colorectal cancer. Seminars in Gastrointestinal Disease, 11(4), 207-18.
Calland JF, et al. Genetic Syndromes and Genetic Tests in Colorectal Cancer. Semin Gastrointest Dis. 2000;11(4):207-18. PubMed PMID: 11057948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic syndromes and genetic tests in colorectal cancer. AU - Calland,J F, AU - Adams,R B, AU - DePrince,K, AU - Foley,E F, AU - Powell,S M, PY - 2000/11/1/pubmed PY - 2001/3/3/medline PY - 2000/11/1/entrez SP - 207 EP - 18 JF - Seminars in gastrointestinal disease JO - Semin. Gastrointest. Dis. VL - 11 IS - 4 N2 - Our understanding of the biology of colon cancer has matured to the point that it is a useful general paradigm for understanding solid tumor development. Recent advances provide insight into the genetic alterations underlying the development of colon cancer. These insights provide unique opportunities for genetic testing in predisposed, asymptomatic patients that can direct screening efforts and their clinical management. This review examines several inherited colon cancer predispositions, well described clinically for a century, that are now amenable to genetic testing. Additional discussion focuses on colon cancer predisposition traits that occur with high frequency but low penetrance characteristics. Finally, genetic tests for tumor markers that potentially have prognostic or therapeutic implications are reviewed. SN - 1049-5118 UR - https://www.unboundmedicine.com/medline/citation/11057948/Genetic_syndromes_and_genetic_tests_in_colorectal_cancer_ L2 - http://www.diseaseinfosearch.org/result/1746 DB - PRIME DP - Unbound Medicine ER -