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Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers.

Abstract

BACKGROUND

Frequent consumption of fruit and vegetables has been associated with a reduced risk of colorectal cancer in many observational studies.

METHODS

We prospectively investigated the association between fruit and vegetable consumption and the incidence of colon and rectal cancers in two large cohorts: the Nurses' Health Study (88 764 women) and the Health Professionals' Follow-up Study (47 325 men). Diet was assessed and cumulatively updated in 1980, 1984, 1986, and 1990 among women and in 1986 and 1990 among men. The incidence of cancer of the colon and rectum was ascertained up to June or January of 1996, respectively. Relative risk (RR) estimates were calculated with the use of pooled logistic regression models accounting for various potential confounders. All statistical tests were two-sided.

RESULTS

With a follow-up including 1 743 645 person-years and 937 cases of colon cancer, we found little association of colon cancer incidence with fruit and vegetable consumption. For women and men combined, a difference in fruit and vegetable consumption of one additional serving per day was associated with a covariate-adjusted RR of 1.02 (95% confidence interval [CI] = 0.98-1.05). A difference in vegetable consumption of one additional serving per day was associated with an RR of 1.03 (95% CI = 0.97-1.09). Similar results were obtained for women and men considered separately. A difference in fruit consumption of one additional serving per day was associated with a covariate-adjusted RR for colon cancer of 0.96 (95% CI = 0.89-1.03) among women and 1. 08 (95% CI = 1.00-1.16) among men. For rectal cancer (total, 244 cases), a difference in fruit and vegetable consumption of one additional serving per day was associated with an RR of 1.02 (95% CI = 0.95-1.09) in men and women combined. None of these associations was modified by vitamin supplement use or smoking habits.

CONCLUSIONS

Although fruits and vegetables may confer protection against some chronic diseases, their frequent consumption does not appear to confer protection from colon or rectal cancer.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kmichels@rics.bwh.harvard.edu

    , , , , , , ,

    Source

    Journal of the National Cancer Institute 92:21 2000 Nov 01 pg 1740-52

    MeSH

    Adult
    Colonic Neoplasms
    Feeding Behavior
    Female
    Fruit
    Humans
    Logistic Models
    Male
    Middle Aged
    Prospective Studies
    Rectal Neoplasms
    Risk
    United States
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11058617

    Citation

    Michels, K B., et al. "Prospective Study of Fruit and Vegetable Consumption and Incidence of Colon and Rectal Cancers." Journal of the National Cancer Institute, vol. 92, no. 21, 2000, pp. 1740-52.
    Michels KB, Edward Giovannucci , Joshipura KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst. 2000;92(21):1740-52.
    Michels, K. B., Edward Giovannucci, ., Joshipura, K. J., Rosner, B. A., Stampfer, M. J., Fuchs, C. S., ... Willett, W. C. (2000). Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. Journal of the National Cancer Institute, 92(21), pp. 1740-52.
    Michels KB, et al. Prospective Study of Fruit and Vegetable Consumption and Incidence of Colon and Rectal Cancers. J Natl Cancer Inst. 2000 Nov 1;92(21):1740-52. PubMed PMID: 11058617.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. AU - Michels,K B, AU - Edward Giovannucci,, AU - Joshipura,K J, AU - Rosner,B A, AU - Stampfer,M J, AU - Fuchs,C S, AU - Colditz,G A, AU - Speizer,F E, AU - Willett,W C, PY - 2000/11/4/pubmed PY - 2001/2/28/medline PY - 2000/11/4/entrez SP - 1740 EP - 52 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 92 IS - 21 N2 - BACKGROUND: Frequent consumption of fruit and vegetables has been associated with a reduced risk of colorectal cancer in many observational studies. METHODS: We prospectively investigated the association between fruit and vegetable consumption and the incidence of colon and rectal cancers in two large cohorts: the Nurses' Health Study (88 764 women) and the Health Professionals' Follow-up Study (47 325 men). Diet was assessed and cumulatively updated in 1980, 1984, 1986, and 1990 among women and in 1986 and 1990 among men. The incidence of cancer of the colon and rectum was ascertained up to June or January of 1996, respectively. Relative risk (RR) estimates were calculated with the use of pooled logistic regression models accounting for various potential confounders. All statistical tests were two-sided. RESULTS: With a follow-up including 1 743 645 person-years and 937 cases of colon cancer, we found little association of colon cancer incidence with fruit and vegetable consumption. For women and men combined, a difference in fruit and vegetable consumption of one additional serving per day was associated with a covariate-adjusted RR of 1.02 (95% confidence interval [CI] = 0.98-1.05). A difference in vegetable consumption of one additional serving per day was associated with an RR of 1.03 (95% CI = 0.97-1.09). Similar results were obtained for women and men considered separately. A difference in fruit consumption of one additional serving per day was associated with a covariate-adjusted RR for colon cancer of 0.96 (95% CI = 0.89-1.03) among women and 1. 08 (95% CI = 1.00-1.16) among men. For rectal cancer (total, 244 cases), a difference in fruit and vegetable consumption of one additional serving per day was associated with an RR of 1.02 (95% CI = 0.95-1.09) in men and women combined. None of these associations was modified by vitamin supplement use or smoking habits. CONCLUSIONS: Although fruits and vegetables may confer protection against some chronic diseases, their frequent consumption does not appear to confer protection from colon or rectal cancer. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/11058617/Prospective_study_of_fruit_and_vegetable_consumption_and_incidence_of_colon_and_rectal_cancers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11058617.ui DB - PRIME DP - Unbound Medicine ER -