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A case-control study of toenail selenium and cancer of the breast, colon, and prostate.

Abstract

To study the possible role of dietary and supplementary selenium intake in the etiology of cancer, we carried out a case-control study of breast, colon, and prostate cancer in Montreal between 1989 and 1993. In this study, we were able to interview a total of 1,048 incidence cases of colon (402), breast (414) and prostate (232) cancer subjects and 688 population-based controls matched for age and gender. Of these, a total of 501 cancer cases and 202 controls produced toenail samples for their selenium concentrations, which were determined by neutron activation analysis. We found no association between toenail selenium and breast cancer (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.4-1.31) or prostate cancer (OR, 1.14; 95% CI, 0.46-2.83), though we did observe a statistically significant inverse association between toenail selenium level and the risk of colon cancer for both genders combined (OR, 0.42; 95% CI, 0.19-0.93; P = .009) and for female subjects (P = .050). We also found that nonsmoker case and control subjects had higher selenium in their toenail samples. This could be due either to the nature of tobacco, which reduces selenium absorption, or to smokers' consumption of certain foods containing less selenium. Further epidemiologic studies are required to clarify the role of selenium in the etiology of certain cancers.

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  • Authors+Show Affiliations

    ,

    Epidemiology Research Unit, Research Center-CHUM, University of Montreal, Quebec, Canada.

    , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Anticarcinogenic Agents
    Biomarkers, Tumor
    Breast Neoplasms
    Case-Control Studies
    Child
    Child, Preschool
    Colonic Neoplasms
    Diet
    Female
    Humans
    Infant
    Logistic Models
    Male
    Middle Aged
    Nails
    Neutron Activation Analysis
    Odds Ratio
    Prostatic Neoplasms
    Selenium
    Smoking
    Toes

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11059562

    Citation

    Ghadirian, P, et al. "A Case-control Study of Toenail Selenium and Cancer of the Breast, Colon, and Prostate." Cancer Detection and Prevention, vol. 24, no. 4, 2000, pp. 305-13.
    Ghadirian P, Maisonneuve P, Perret C, et al. A case-control study of toenail selenium and cancer of the breast, colon, and prostate. Cancer Detect Prev. 2000;24(4):305-13.
    Ghadirian, P., Maisonneuve, P., Perret, C., Kennedy, G., Boyle, P., Krewski, D., & Lacroix, A. (2000). A case-control study of toenail selenium and cancer of the breast, colon, and prostate. Cancer Detection and Prevention, 24(4), pp. 305-13.
    Ghadirian P, et al. A Case-control Study of Toenail Selenium and Cancer of the Breast, Colon, and Prostate. Cancer Detect Prev. 2000;24(4):305-13. PubMed PMID: 11059562.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A case-control study of toenail selenium and cancer of the breast, colon, and prostate. AU - Ghadirian,P, AU - Maisonneuve,P, AU - Perret,C, AU - Kennedy,G, AU - Boyle,P, AU - Krewski,D, AU - Lacroix,A, PY - 2000/11/4/pubmed PY - 2001/3/3/medline PY - 2000/11/4/entrez SP - 305 EP - 13 JF - Cancer detection and prevention JO - Cancer Detect. Prev. VL - 24 IS - 4 N2 - To study the possible role of dietary and supplementary selenium intake in the etiology of cancer, we carried out a case-control study of breast, colon, and prostate cancer in Montreal between 1989 and 1993. In this study, we were able to interview a total of 1,048 incidence cases of colon (402), breast (414) and prostate (232) cancer subjects and 688 population-based controls matched for age and gender. Of these, a total of 501 cancer cases and 202 controls produced toenail samples for their selenium concentrations, which were determined by neutron activation analysis. We found no association between toenail selenium and breast cancer (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.4-1.31) or prostate cancer (OR, 1.14; 95% CI, 0.46-2.83), though we did observe a statistically significant inverse association between toenail selenium level and the risk of colon cancer for both genders combined (OR, 0.42; 95% CI, 0.19-0.93; P = .009) and for female subjects (P = .050). We also found that nonsmoker case and control subjects had higher selenium in their toenail samples. This could be due either to the nature of tobacco, which reduces selenium absorption, or to smokers' consumption of certain foods containing less selenium. Further epidemiologic studies are required to clarify the role of selenium in the etiology of certain cancers. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/11059562/A_case_control_study_of_toenail_selenium_and_cancer_of_the_breast_colon_and_prostate_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11059562.ui DB - PRIME DP - Unbound Medicine ER -