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Cellular immune activation, neopterin production, tryptophan degradation and the development of immunodeficiency.
Arch Immunol Ther Exp (Warsz) 2000; 48(4):251-8AI

Abstract

Cellular (Th1-type) immune response is centrally involved in the pathogenesis of various diseases. Within the immunological cascades of Th1-type immunity, interferon gamma (IFN-gamma), among other cytokines, is critically involved. It triggers a series of immune-relevant reactions mostly directed towards forward regulation of the antigen specific immune response. However, in chronic states of immune activation, systemically increased IFN-gamma is no longer antigen specific and is associated with the development of immunodeficiency. IFN-gamma also stimulates the production of neopterin, a low-mass compound, in human monocytes/macrophages. Accordingly, neopterin concentrations in humans reflect the degree of Th1-type immune activation. Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. In parallel, IFN-gamma activates the degradation of tryptophan, which appears to limit the growth of intracellular pathogens and the proliferation of cells, including T lymphocytes. Thus, during persisting states of immune activation, the production of IFN-gamma is not only associated with forward regulation of the immune response, but also with immunosuppressive mechanisms. The increased formation of neopterin and degradation of tryptophan may result in a decreased T cell responsiveness and development of immunodeficiency.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11059641

Citation

Widner, B, et al. "Cellular Immune Activation, Neopterin Production, Tryptophan Degradation and the Development of Immunodeficiency." Archivum Immunologiae Et Therapiae Experimentalis, vol. 48, no. 4, 2000, pp. 251-8.
Widner B, Wirleitner B, Baier-Bitterlich G, et al. Cellular immune activation, neopterin production, tryptophan degradation and the development of immunodeficiency. Arch Immunol Ther Exp (Warsz). 2000;48(4):251-8.
Widner, B., Wirleitner, B., Baier-Bitterlich, G., Weiss, G., & Fuchs, D. (2000). Cellular immune activation, neopterin production, tryptophan degradation and the development of immunodeficiency. Archivum Immunologiae Et Therapiae Experimentalis, 48(4), pp. 251-8.
Widner B, et al. Cellular Immune Activation, Neopterin Production, Tryptophan Degradation and the Development of Immunodeficiency. Arch Immunol Ther Exp (Warsz). 2000;48(4):251-8. PubMed PMID: 11059641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular immune activation, neopterin production, tryptophan degradation and the development of immunodeficiency. AU - Widner,B, AU - Wirleitner,B, AU - Baier-Bitterlich,G, AU - Weiss,G, AU - Fuchs,D, PY - 2000/11/4/pubmed PY - 2001/3/7/medline PY - 2000/11/4/entrez SP - 251 EP - 8 JF - Archivum immunologiae et therapiae experimentalis JO - Arch. Immunol. Ther. Exp. (Warsz.) VL - 48 IS - 4 N2 - Cellular (Th1-type) immune response is centrally involved in the pathogenesis of various diseases. Within the immunological cascades of Th1-type immunity, interferon gamma (IFN-gamma), among other cytokines, is critically involved. It triggers a series of immune-relevant reactions mostly directed towards forward regulation of the antigen specific immune response. However, in chronic states of immune activation, systemically increased IFN-gamma is no longer antigen specific and is associated with the development of immunodeficiency. IFN-gamma also stimulates the production of neopterin, a low-mass compound, in human monocytes/macrophages. Accordingly, neopterin concentrations in humans reflect the degree of Th1-type immune activation. Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. In parallel, IFN-gamma activates the degradation of tryptophan, which appears to limit the growth of intracellular pathogens and the proliferation of cells, including T lymphocytes. Thus, during persisting states of immune activation, the production of IFN-gamma is not only associated with forward regulation of the immune response, but also with immunosuppressive mechanisms. The increased formation of neopterin and degradation of tryptophan may result in a decreased T cell responsiveness and development of immunodeficiency. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/11059641/Cellular_immune_activation_neopterin_production_tryptophan_degradation_and_the_development_of_immunodeficiency_ L2 - https://www.lens.org/lens/search?q=citation_id:11059641 DB - PRIME DP - Unbound Medicine ER -