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Actions of melatonin in the reduction of oxidative stress. A review.
J Biomed Sci. 2000 Nov-Dec; 7(6):444-58.JB

Abstract

Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Additionally, melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. The following antioxidative enzymes are also stimulated by melatonin: superoxide dismutase, glutathione peroxidase and glutathione reductase. Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms.

Authors+Show Affiliations

Reiter RJ
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Reiter@uthscsa.edu
Tan DX
No affiliation info available
Osuna C
No affiliation info available
Gitto E
No affiliation info available

MeSH

AnimalsAntioxidantsEnzymesFree Radical ScavengersHumansMelatoninOxidative StressOxygenReactive Oxygen Species

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11060493

Citation

Reiter, R J., et al. "Actions of Melatonin in the Reduction of Oxidative Stress. a Review." Journal of Biomedical Science, vol. 7, no. 6, 2000, pp. 444-58.
Reiter RJ, Tan DX, Osuna C, et al. Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci. 2000;7(6):444-58.
Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000). Actions of melatonin in the reduction of oxidative stress. A review. Journal of Biomedical Science, 7(6), 444-58.
Reiter RJ, et al. Actions of Melatonin in the Reduction of Oxidative Stress. a Review. J Biomed Sci. 2000 Nov-Dec;7(6):444-58. PubMed PMID: 11060493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Actions of melatonin in the reduction of oxidative stress. A review. AU - Reiter,R J, AU - Tan,D X, AU - Osuna,C, AU - Gitto,E, PY - 2000/11/4/pubmed PY - 2001/2/28/medline PY - 2000/11/4/entrez SP - 444 EP - 58 JF - Journal of biomedical science JO - J Biomed Sci VL - 7 IS - 6 N2 - Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Additionally, melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. The following antioxidative enzymes are also stimulated by melatonin: superoxide dismutase, glutathione peroxidase and glutathione reductase. Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms. SN - 1021-7770 UR - https://www.unboundmedicine.com/medline/citation/11060493/Actions_of_melatonin_in_the_reduction_of_oxidative_stress__A_review_ DB - PRIME DP - Unbound Medicine ER -