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Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 1).
Anticancer Res 2000 Sep-Oct; 20(5A):2899-906AR

Abstract

A methanol extract (500 mg/kg x 2/day) of the heartwood of Cassia garrettiana inhibited the tumor growth and metastasis to the lung in Lewis lung carcinoma (LLC)-bearing mice. We isolated the two active substances from the methanol extract of C. garrettiana: compound 1 was identified as Cassigarol A and the determination of the structure of compound 2 is now in progress. We examined the effect of the active substance (compound 1, Cassigarol A) on tumor growth and lung metastasis in LLC-bearing and primary tumor-removed mice and found that Cassigarol A (50 mg and 100 mg/kg x 2/day) inhibited the tumor growth and metastasis to the lung. In addition, Cassigarol A inhibited the plasmin activity and the formation of capillary-like networks of human umbilical vein endothelial cells (HUVECs) at concentrations of 10 to 100 microM. Therefore, it is suggested that the antitumor and antimetastatic activities of Cassigarol A might be due to the inhibition of plasmin activity and formation of tubes (angiogenesis) from HUVECs.

Authors+Show Affiliations

Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan. yokim@m.ehime-u.acjpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11062699

Citation

Kimura, Y, et al. "Inhibitory Effects of Active Substances Isolated From Cassia Garrettiana Heartwood On Tumor Growth and Lung Metastasis in Lewis Lung Carcinoma-bearing Mice (Part 1)." Anticancer Research, vol. 20, no. 5A, 2000, pp. 2899-906.
Kimura Y, Baba K, Okuda H. Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 1). Anticancer Res. 2000;20(5A):2899-906.
Kimura, Y., Baba, K., & Okuda, H. (2000). Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 1). Anticancer Research, 20(5A), pp. 2899-906.
Kimura Y, Baba K, Okuda H. Inhibitory Effects of Active Substances Isolated From Cassia Garrettiana Heartwood On Tumor Growth and Lung Metastasis in Lewis Lung Carcinoma-bearing Mice (Part 1). Anticancer Res. 2000;20(5A):2899-906. PubMed PMID: 11062699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 1). AU - Kimura,Y, AU - Baba,K, AU - Okuda,H, PY - 2000/11/4/pubmed PY - 2001/2/28/medline PY - 2000/11/4/entrez SP - 2899 EP - 906 JF - Anticancer research JO - Anticancer Res. VL - 20 IS - 5A N2 - A methanol extract (500 mg/kg x 2/day) of the heartwood of Cassia garrettiana inhibited the tumor growth and metastasis to the lung in Lewis lung carcinoma (LLC)-bearing mice. We isolated the two active substances from the methanol extract of C. garrettiana: compound 1 was identified as Cassigarol A and the determination of the structure of compound 2 is now in progress. We examined the effect of the active substance (compound 1, Cassigarol A) on tumor growth and lung metastasis in LLC-bearing and primary tumor-removed mice and found that Cassigarol A (50 mg and 100 mg/kg x 2/day) inhibited the tumor growth and metastasis to the lung. In addition, Cassigarol A inhibited the plasmin activity and the formation of capillary-like networks of human umbilical vein endothelial cells (HUVECs) at concentrations of 10 to 100 microM. Therefore, it is suggested that the antitumor and antimetastatic activities of Cassigarol A might be due to the inhibition of plasmin activity and formation of tubes (angiogenesis) from HUVECs. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/11062699/Inhibitory_effects_of_active_substances_isolated_from_Cassia_garrettiana_heartwood_on_tumor_growth_and_lung_metastasis_in_Lewis_lung_carcinoma_bearing_mice__Part_1__ L2 - https://medlineplus.gov/lungcancer.html DB - PRIME DP - Unbound Medicine ER -