Tags

Type your tag names separated by a space and hit enter

Plasma lipid profiles in adults after prenatal exposure to the Dutch famine.
Am J Clin Nutr 2000; 72(5):1101-6AJ

Abstract

BACKGROUND

Small body size at birth has been reported to be associated with an atherogenic lipid profile in humans, and animal experiments have shown that undernutrition during pregnancy permanently alters cholesterol metabolism in the offspring. There is no direct evidence in humans that maternal malnutrition during pregnancy affects the lipid profiles of the offspring.

OBJECTIVES

We assessed the effects of maternal malnutrition during specific periods of gestation on plasma lipid profiles in persons aged approximately 50 y.

DESIGN

This was a follow-up study of men and women born at term as singletons in a university hospital in Amsterdam between 1 November 1943 and 28 February 1947 around the time of a severe famine.

RESULTS

Persons exposed to famine in early gestation had a more atherogenic lipid profile than did those who were not exposed to famine in utero. Their LDL-HDL cholesterol ratios were significantly higher (by 13.9%; 95% CI: 2.6-26.4%). Additionally, their plasma HDL-cholesterol and apolipoprotein A concentrations tended to be lower, and their plasma total cholesterol, LDL-cholesterol, and apolipoprotein B concentrations tended to be higher, although these differences were not statistically significant. The effect of famine was independent of size at birth and adult obesity.

CONCLUSIONS

An atherogenic lipid profile might be linked to a transition from poor maternal nutrition in early gestation to adequate nutrition later on. This suggests that maternal malnutrition during early gestation may program lipid metabolism without affecting size at birth.

Authors+Show Affiliations

Departments of Clinical Epidemiology and Biostatistics and Obstetrics and Gynecology, the Academic Medical Center, the University of Amsterdam, Netherlands. t.j.roseboom@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11063435

Citation

Roseboom, T J., et al. "Plasma Lipid Profiles in Adults After Prenatal Exposure to the Dutch Famine." The American Journal of Clinical Nutrition, vol. 72, no. 5, 2000, pp. 1101-6.
Roseboom TJ, van der Meulen JH, Osmond C, et al. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2000;72(5):1101-6.
Roseboom, T. J., van der Meulen, J. H., Osmond, C., Barker, D. J., Ravelli, A. C., & Bleker, O. P. (2000). Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. The American Journal of Clinical Nutrition, 72(5), pp. 1101-6.
Roseboom TJ, et al. Plasma Lipid Profiles in Adults After Prenatal Exposure to the Dutch Famine. Am J Clin Nutr. 2000;72(5):1101-6. PubMed PMID: 11063435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. AU - Roseboom,T J, AU - van der Meulen,J H, AU - Osmond,C, AU - Barker,D J, AU - Ravelli,A C, AU - Bleker,O P, PY - 2000/11/4/pubmed PY - 2001/2/28/medline PY - 2000/11/4/entrez SP - 1101 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 72 IS - 5 N2 - BACKGROUND: Small body size at birth has been reported to be associated with an atherogenic lipid profile in humans, and animal experiments have shown that undernutrition during pregnancy permanently alters cholesterol metabolism in the offspring. There is no direct evidence in humans that maternal malnutrition during pregnancy affects the lipid profiles of the offspring. OBJECTIVES: We assessed the effects of maternal malnutrition during specific periods of gestation on plasma lipid profiles in persons aged approximately 50 y. DESIGN: This was a follow-up study of men and women born at term as singletons in a university hospital in Amsterdam between 1 November 1943 and 28 February 1947 around the time of a severe famine. RESULTS: Persons exposed to famine in early gestation had a more atherogenic lipid profile than did those who were not exposed to famine in utero. Their LDL-HDL cholesterol ratios were significantly higher (by 13.9%; 95% CI: 2.6-26.4%). Additionally, their plasma HDL-cholesterol and apolipoprotein A concentrations tended to be lower, and their plasma total cholesterol, LDL-cholesterol, and apolipoprotein B concentrations tended to be higher, although these differences were not statistically significant. The effect of famine was independent of size at birth and adult obesity. CONCLUSIONS: An atherogenic lipid profile might be linked to a transition from poor maternal nutrition in early gestation to adequate nutrition later on. This suggests that maternal malnutrition during early gestation may program lipid metabolism without affecting size at birth. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11063435/Plasma_lipid_profiles_in_adults_after_prenatal_exposure_to_the_Dutch_famine_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/72.5.1101 DB - PRIME DP - Unbound Medicine ER -