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A prospective study of cigarette smoking and the incidence of diabetes mellitus among US male physicians.
Am J Med 2000; 109(7):538-42AJ

Abstract

PURPOSE

To determine the association between cigarette smoking and the incidence of type 2 diabetes mellitus.

SUBJECTS AND METHODS

We studied 21,068 US male physicians aged 40 to 84 years in the Physicians' Health Study who were initially free of diagnosed diabetes mellitus, cardiovascular disease, and cancer. Information about cigarette smoking and other risk indicators was obtained at baseline. The primary outcome was reported diagnosis of type 2 diabetes mellitus.

RESULTS

During 255,830 person-years of follow-up, 770 new cases of type 2 diabetes mellitus were identified. Smokers had a dose-dependent increased risk of developing type 2 diabetes mellitus: compared with never smokers, the age-adjusted relative risk was 2.1 (95% confidence interval [CI]: 1.7 to 2.6) for current smokers of > or = 20 cigarettes per day, 1.4 (95% CI: 1.0 to 2.0) for current smokers of <20 cigarettes per day, and 1.2 (95% CI: 1.0 to 1.4) for past smokers. After multivariate adjustment for body mass index, physical activity, and other risk factors, the relative risks were 1.7 (95% CI: 1.3 to 2.3) for current smokers of > or = 20 cigarettes per day, 1.5 (95% CI: 1.0 to 2.2) for current smokers of <20 cigarettes per day, and 1.1 (95% CI: 1.0 to 1.4) for past smokers. Total pack-years of cigarette smoking was also associated with the risk of type 2 diabetes mellitus (P for trend <0.001).

CONCLUSIONS

These prospective data support the hypothesis that cigarette smoking is an independent and modifiable determinant of type 2 diabetes mellitus.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11063954

Citation

Manson, J E., et al. "A Prospective Study of Cigarette Smoking and the Incidence of Diabetes Mellitus Among US Male Physicians." The American Journal of Medicine, vol. 109, no. 7, 2000, pp. 538-42.
Manson JE, Ajani UA, Liu S, et al. A prospective study of cigarette smoking and the incidence of diabetes mellitus among US male physicians. Am J Med. 2000;109(7):538-42.
Manson, J. E., Ajani, U. A., Liu, S., Nathan, D. M., & Hennekens, C. H. (2000). A prospective study of cigarette smoking and the incidence of diabetes mellitus among US male physicians. The American Journal of Medicine, 109(7), pp. 538-42.
Manson JE, et al. A Prospective Study of Cigarette Smoking and the Incidence of Diabetes Mellitus Among US Male Physicians. Am J Med. 2000;109(7):538-42. PubMed PMID: 11063954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of cigarette smoking and the incidence of diabetes mellitus among US male physicians. AU - Manson,J E, AU - Ajani,U A, AU - Liu,S, AU - Nathan,D M, AU - Hennekens,C H, PY - 2000/11/7/pubmed PY - 2001/2/28/medline PY - 2000/11/7/entrez SP - 538 EP - 42 JF - The American journal of medicine JO - Am. J. Med. VL - 109 IS - 7 N2 - PURPOSE: To determine the association between cigarette smoking and the incidence of type 2 diabetes mellitus. SUBJECTS AND METHODS: We studied 21,068 US male physicians aged 40 to 84 years in the Physicians' Health Study who were initially free of diagnosed diabetes mellitus, cardiovascular disease, and cancer. Information about cigarette smoking and other risk indicators was obtained at baseline. The primary outcome was reported diagnosis of type 2 diabetes mellitus. RESULTS: During 255,830 person-years of follow-up, 770 new cases of type 2 diabetes mellitus were identified. Smokers had a dose-dependent increased risk of developing type 2 diabetes mellitus: compared with never smokers, the age-adjusted relative risk was 2.1 (95% confidence interval [CI]: 1.7 to 2.6) for current smokers of > or = 20 cigarettes per day, 1.4 (95% CI: 1.0 to 2.0) for current smokers of <20 cigarettes per day, and 1.2 (95% CI: 1.0 to 1.4) for past smokers. After multivariate adjustment for body mass index, physical activity, and other risk factors, the relative risks were 1.7 (95% CI: 1.3 to 2.3) for current smokers of > or = 20 cigarettes per day, 1.5 (95% CI: 1.0 to 2.2) for current smokers of <20 cigarettes per day, and 1.1 (95% CI: 1.0 to 1.4) for past smokers. Total pack-years of cigarette smoking was also associated with the risk of type 2 diabetes mellitus (P for trend <0.001). CONCLUSIONS: These prospective data support the hypothesis that cigarette smoking is an independent and modifiable determinant of type 2 diabetes mellitus. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/11063954/A_prospective_study_of_cigarette_smoking_and_the_incidence_of_diabetes_mellitus_among_US_male_physicians_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(00)00568-4 DB - PRIME DP - Unbound Medicine ER -