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Breastfeeding and breast cancer risk by age 50 among women in Germany.

Abstract

BACKGROUND

Epidemiological evidence which suggests that prolonged breastfeeding protects against breast cancer has accumulated in recent years. Issues with regard to the timing of breastfeeding and effect modification by correlates of breastfeeding and other risk factors of breast cancer remain unresolved.

METHODS

A population-based case control family study of breast cancer among women diagnosed by the age of 50, conducted in two geographic areas in Germany, was used to evaluate the effect of breastfeeding on risk of breast cancer.

RESULTS

Among parous women in this study (553 cases, 1094 age-matched population controls), having ever breastfed a child for at least 1 month did not confer protection (odds ratio of 0.9 and 95% confidence interval (CI) 0.8-1.2). However, risk of breast cancer significantly decreased with increasing duration of breastfeeding (p for trend = 0.01) and the estimated relative risk was 0.6 (95% CI 0.4-0.9) for 13-24 months of cumulative breastfeeding and 0.5 (95% CI 0.3-1.1) for 25 months or more. Risk was less related to number of children breastfed than to increasing average length of breastfeeding per child (p for trend = 0.03).

CONCLUSIONS

The reduction in risk associated with duration of breastfeeding was not primarily due to breastfeeding the firstborn and more evident in women who were older (> 25 years) when they first breastfed and among women who experienced a recent full-term pregnancy. Risks were modified somewhat by a first-degree family history of breast cancer whereby a greater reduction in risk per additional month of breastfeeding was observed among women with a family history than those without (0.9 vs. 1.0). The study results support a protective role of prolonged breastfeeding against the development of breast cancer in predominantly premenopausal women in Germany.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, Deutsches Krebsforschungs Zentrum, Heidelberg, Germany. j-chang-claude@dkfz-heidelberg.de

    , , ,

    Source

    Cancer causes & control : CCC 11:8 2000 Sep pg 687-95

    MeSH

    Adult
    Age Factors
    Breast Feeding
    Breast Neoplasms
    Female
    Germany
    Humans
    Middle Aged
    Risk Factors
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11065005

    Citation

    Chang-Claude, J, et al. "Breastfeeding and Breast Cancer Risk By Age 50 Among Women in Germany." Cancer Causes & Control : CCC, vol. 11, no. 8, 2000, pp. 687-95.
    Chang-Claude J, Eby N, Kiechle M, et al. Breastfeeding and breast cancer risk by age 50 among women in Germany. Cancer Causes Control. 2000;11(8):687-95.
    Chang-Claude, J., Eby, N., Kiechle, M., Bastert, G., & Becher, H. (2000). Breastfeeding and breast cancer risk by age 50 among women in Germany. Cancer Causes & Control : CCC, 11(8), pp. 687-95.
    Chang-Claude J, et al. Breastfeeding and Breast Cancer Risk By Age 50 Among Women in Germany. Cancer Causes Control. 2000;11(8):687-95. PubMed PMID: 11065005.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breastfeeding and breast cancer risk by age 50 among women in Germany. AU - Chang-Claude,J, AU - Eby,N, AU - Kiechle,M, AU - Bastert,G, AU - Becher,H, PY - 2000/11/7/pubmed PY - 2001/4/3/medline PY - 2000/11/7/entrez SP - 687 EP - 95 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 11 IS - 8 N2 - BACKGROUND: Epidemiological evidence which suggests that prolonged breastfeeding protects against breast cancer has accumulated in recent years. Issues with regard to the timing of breastfeeding and effect modification by correlates of breastfeeding and other risk factors of breast cancer remain unresolved. METHODS: A population-based case control family study of breast cancer among women diagnosed by the age of 50, conducted in two geographic areas in Germany, was used to evaluate the effect of breastfeeding on risk of breast cancer. RESULTS: Among parous women in this study (553 cases, 1094 age-matched population controls), having ever breastfed a child for at least 1 month did not confer protection (odds ratio of 0.9 and 95% confidence interval (CI) 0.8-1.2). However, risk of breast cancer significantly decreased with increasing duration of breastfeeding (p for trend = 0.01) and the estimated relative risk was 0.6 (95% CI 0.4-0.9) for 13-24 months of cumulative breastfeeding and 0.5 (95% CI 0.3-1.1) for 25 months or more. Risk was less related to number of children breastfed than to increasing average length of breastfeeding per child (p for trend = 0.03). CONCLUSIONS: The reduction in risk associated with duration of breastfeeding was not primarily due to breastfeeding the firstborn and more evident in women who were older (> 25 years) when they first breastfed and among women who experienced a recent full-term pregnancy. Risks were modified somewhat by a first-degree family history of breast cancer whereby a greater reduction in risk per additional month of breastfeeding was observed among women with a family history than those without (0.9 vs. 1.0). The study results support a protective role of prolonged breastfeeding against the development of breast cancer in predominantly premenopausal women in Germany. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/11065005/Breastfeeding_and_breast_cancer_risk_by_age_50_among_women_in_Germany_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11065005.ui DB - PRIME DP - Unbound Medicine ER -