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[Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored].
Lakartidningen. 2000 Sep 20; 97(38):4131-4, 4136.L

Abstract

Cobalamin/folate deficiency in elderly subjects may lead to psychiatric symptoms. Most studies concerning the relation between mental disorders in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect vitamin status in the tissues. Two new markers, plasma homocysteine and serum methylmalonic acid, have attracted growing interest since they are considered to reflect the functional status of cobalamins and folates in the tissues. This review summarizes present findings concerning the different markers for cobalamin/folate deficiency as well as their association with functional parameters of the central nervous system such as cognitive and behavioral performance. Plasma homocysteine seems to be much more closely associated with neuropsychiatric dysfunction than is plasma methylmalonic acid.

Authors+Show Affiliations

Hultberg B
Kliniskt kemiska laboratoriet, Universitetssjukhuset i Lund.
Isaksson A
No affiliation info available
Nilsson K
No affiliation info available
Gustafson L
No affiliation info available

MeSH

AgedBiomarkersCognition DisordersDiagnosis, DifferentialFolic Acid DeficiencyGeriatric PsychiatryHomocysteineHumansMental DisordersMethylmalonic AcidReference ValuesVitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article
Review

Language

swe

PubMed ID

11068379

Citation

Hultberg, B, et al. "[Homocysteine and Methylmalonic Acid as Markers of Cobalamin/folate Status. the Association to Neuropsychiatric Symptoms in the Elderly Is Explored]." Lakartidningen, vol. 97, no. 38, 2000, pp. 4131-4, 4136.
Hultberg B, Isaksson A, Nilsson K, et al. [Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored]. Lakartidningen. 2000;97(38):4131-4, 4136.
Hultberg, B., Isaksson, A., Nilsson, K., & Gustafson, L. (2000). [Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored]. Lakartidningen, 97(38), 4131-4, 4136.
Hultberg B, et al. [Homocysteine and Methylmalonic Acid as Markers of Cobalamin/folate Status. the Association to Neuropsychiatric Symptoms in the Elderly Is Explored]. Lakartidningen. 2000 Sep 20;97(38):4131-4, 4136. PubMed PMID: 11068379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored]. AU - Hultberg,B, AU - Isaksson,A, AU - Nilsson,K, AU - Gustafson,L, PY - 2000/11/9/pubmed PY - 2001/2/28/medline PY - 2000/11/9/entrez SP - 4131-4, 4136 JF - Lakartidningen JO - Lakartidningen VL - 97 IS - 38 N2 - Cobalamin/folate deficiency in elderly subjects may lead to psychiatric symptoms. Most studies concerning the relation between mental disorders in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect vitamin status in the tissues. Two new markers, plasma homocysteine and serum methylmalonic acid, have attracted growing interest since they are considered to reflect the functional status of cobalamins and folates in the tissues. This review summarizes present findings concerning the different markers for cobalamin/folate deficiency as well as their association with functional parameters of the central nervous system such as cognitive and behavioral performance. Plasma homocysteine seems to be much more closely associated with neuropsychiatric dysfunction than is plasma methylmalonic acid. SN - 0023-7205 UR - https://www.unboundmedicine.com/medline/citation/11068379/[Homocysteine_and_methylmalonic_acid_as_markers_of_cobalamin/folate_status__The_association_to_neuropsychiatric_symptoms_in_the_elderly_is_explored]_ DB - PRIME DP - Unbound Medicine ER -