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CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions.
Eur J Immunol. 2000 Oct; 30(10):3061-5.EJ

Abstract

CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and bound cells became much more resistant to detachment forces and spread. T cell arrest occurred within 1 min and was dependent on the alpha4beta1-VCAM-1 pathway. In contrast, the alphaLbeta2-ICAM-1 pathway remained unactivated. This was observed with T cell lines and with activated peripheral blood lymphocytes, and was limited within the resting peripheral CD4+ T cells to the memory subset, while virgin cells were unaffected. This discloses a stepwise regulation of the T cell extravasation cascade.

Authors+Show Affiliations

INSERM U343 et Laboratoire d'Immunologie, Université de Nice-Sophia Antipolis, Nice, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11069091

Citation

Bernard, G, et al. "CD99 (E2) Up-regulates Alpha4beta1-dependent T Cell Adhesion to Inflamed Vascular Endothelium Under Flow Conditions." European Journal of Immunology, vol. 30, no. 10, 2000, pp. 3061-5.
Bernard G, Raimondi V, Alberti I, et al. CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions. Eur J Immunol. 2000;30(10):3061-5.
Bernard, G., Raimondi, V., Alberti, I., Pourtein, M., Widjenes, J., Ticchioni, M., & Bernard, A. (2000). CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions. European Journal of Immunology, 30(10), 3061-5.
Bernard G, et al. CD99 (E2) Up-regulates Alpha4beta1-dependent T Cell Adhesion to Inflamed Vascular Endothelium Under Flow Conditions. Eur J Immunol. 2000;30(10):3061-5. PubMed PMID: 11069091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions. AU - Bernard,G, AU - Raimondi,V, AU - Alberti,I, AU - Pourtein,M, AU - Widjenes,J, AU - Ticchioni,M, AU - Bernard,A, PY - 2000/11/9/pubmed PY - 2001/2/28/medline PY - 2000/11/9/entrez SP - 3061 EP - 5 JF - European journal of immunology JO - Eur J Immunol VL - 30 IS - 10 N2 - CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and bound cells became much more resistant to detachment forces and spread. T cell arrest occurred within 1 min and was dependent on the alpha4beta1-VCAM-1 pathway. In contrast, the alphaLbeta2-ICAM-1 pathway remained unactivated. This was observed with T cell lines and with activated peripheral blood lymphocytes, and was limited within the resting peripheral CD4+ T cells to the memory subset, while virgin cells were unaffected. This discloses a stepwise regulation of the T cell extravasation cascade. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/11069091/CD99__E2__up_regulates_alpha4beta1_dependent_T_cell_adhesion_to_inflamed_vascular_endothelium_under_flow_conditions_ L2 - https://doi.org/10.1002/1521-4141(200010)30:10<3061::AID-IMMU3061>3.0.CO;2-M DB - PRIME DP - Unbound Medicine ER -