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Serum transferrin and serum prealbumin are early predictors of serum albumin in chronic hemodialysis patients.

Abstract

Protein-calorie malnutrition is a known risk factor for increased morbidity and mortality in maintenance hemodialysis patients (MHD). Serum albumin is the most commonly measured nutritional index in MHD patients because of its easy routine availability and association with outcomes of interest. However, its long half-life of approximately 20 days makes it a late index of nutritional status, and its exclusive use may delay implementation of appropriate nutritional interventions. Serum prealbumin and transferrin have been proposed as earlier nutritional markers. However, the temporal associations among these indices and serum albumin have not been well documented. To assess the ability of serum prealbumin and serum transferrin to predict changes in serum albumin over time, we prospectively analyzed these parameters in 105 MHD patients every month for 6 consecutive months. The mixed model analysis showed that early changes in either serum transferrin or prealbumin predicted and were significantly associated with changes in serum albumin (P<.0001). Using a prototype equation, a change of 0.12 g/dL in serum albumin concentration can be predicted by a 10% change in the same direction of serum transferrin and prealbumin. We conclude that clinically significant changes in albumin can be reliably predicted by earlier changes in serum transferrin and prealbumin.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.

    , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Biomarkers
    Cohort Studies
    Female
    Half-Life
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Nutritional Status
    Prealbumin
    Prospective Studies
    Protein-Energy Malnutrition
    Renal Dialysis
    Serum Albumin
    Transferrin

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11070145

    Citation

    Neyra, N R., et al. "Serum Transferrin and Serum Prealbumin Are Early Predictors of Serum Albumin in Chronic Hemodialysis Patients." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 10, no. 4, 2000, pp. 184-90.
    Neyra NR, Hakim RM, Shyr Y, et al. Serum transferrin and serum prealbumin are early predictors of serum albumin in chronic hemodialysis patients. J Ren Nutr. 2000;10(4):184-90.
    Neyra, N. R., Hakim, R. M., Shyr, Y., & Ikizler, T. A. (2000). Serum transferrin and serum prealbumin are early predictors of serum albumin in chronic hemodialysis patients. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 10(4), pp. 184-90.
    Neyra NR, et al. Serum Transferrin and Serum Prealbumin Are Early Predictors of Serum Albumin in Chronic Hemodialysis Patients. J Ren Nutr. 2000;10(4):184-90. PubMed PMID: 11070145.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum transferrin and serum prealbumin are early predictors of serum albumin in chronic hemodialysis patients. AU - Neyra,N R, AU - Hakim,R M, AU - Shyr,Y, AU - Ikizler,T A, PY - 2000/11/9/pubmed PY - 2001/3/10/medline PY - 2000/11/9/entrez SP - 184 EP - 90 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 10 IS - 4 N2 - Protein-calorie malnutrition is a known risk factor for increased morbidity and mortality in maintenance hemodialysis patients (MHD). Serum albumin is the most commonly measured nutritional index in MHD patients because of its easy routine availability and association with outcomes of interest. However, its long half-life of approximately 20 days makes it a late index of nutritional status, and its exclusive use may delay implementation of appropriate nutritional interventions. Serum prealbumin and transferrin have been proposed as earlier nutritional markers. However, the temporal associations among these indices and serum albumin have not been well documented. To assess the ability of serum prealbumin and serum transferrin to predict changes in serum albumin over time, we prospectively analyzed these parameters in 105 MHD patients every month for 6 consecutive months. The mixed model analysis showed that early changes in either serum transferrin or prealbumin predicted and were significantly associated with changes in serum albumin (P<.0001). Using a prototype equation, a change of 0.12 g/dL in serum albumin concentration can be predicted by a 10% change in the same direction of serum transferrin and prealbumin. We conclude that clinically significant changes in albumin can be reliably predicted by earlier changes in serum transferrin and prealbumin. SN - 1051-2276 UR - https://www.unboundmedicine.com/medline/citation/11070145/Serum_transferrin_and_serum_prealbumin_are_early_predictors_of_serum_albumin_in_chronic_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051227600471487 DB - PRIME DP - Unbound Medicine ER -