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Pentoxifylline. Adjunctive therapy in the treatment of pedal frostbite.
Clin Podiatr Med Surg. 2000 Oct; 17(4):715-22.CP

Abstract

Frostbite injury to the extremities has the potential for disastrous effects. Prompt recognition and treatment are paramount. The use of Pentoxifylline to minimize tissue damage in the treatment of frostbite is a viable addition to the traditional therapy of rewarming soaks, pain management, and vesicle débridement. The most well known action of Pentoxifylline is its ability to increase RBC flexibility, allowing easier vascularization. This explains its indication for PVD, arterial disease, and intermittent claudication. As is explained previously, however, Pentoxifylline has multiple actions that will enhance tissue survival. The dosage of Pentoxifylline in controlled release tablet form is one 400 mg tablet three times a day with meals. The duration of treatment should be from two to six weeks. As this drug has many actions and therefore possibilities, more research is warranted with regards to its use not only with frostbite, but with other pathological processes.

Authors+Show Affiliations

Department of Podiatric Surgery and Traumatology, Broadlawns Medical Center, Des Moines, Iowa, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11070801

Citation

Hayes, D W., et al. "Pentoxifylline. Adjunctive Therapy in the Treatment of Pedal Frostbite." Clinics in Podiatric Medicine and Surgery, vol. 17, no. 4, 2000, pp. 715-22.
Hayes DW, Mandracchia VJ, Considine C, et al. Pentoxifylline. Adjunctive therapy in the treatment of pedal frostbite. Clin Podiatr Med Surg. 2000;17(4):715-22.
Hayes, D. W., Mandracchia, V. J., Considine, C., & Webb, G. E. (2000). Pentoxifylline. Adjunctive therapy in the treatment of pedal frostbite. Clinics in Podiatric Medicine and Surgery, 17(4), 715-22.
Hayes DW, et al. Pentoxifylline. Adjunctive Therapy in the Treatment of Pedal Frostbite. Clin Podiatr Med Surg. 2000;17(4):715-22. PubMed PMID: 11070801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline. Adjunctive therapy in the treatment of pedal frostbite. AU - Hayes,D W,Jr AU - Mandracchia,V J, AU - Considine,C, AU - Webb,G E, PY - 2000/11/9/pubmed PY - 2001/3/3/medline PY - 2000/11/9/entrez SP - 715 EP - 22 JF - Clinics in podiatric medicine and surgery JO - Clin Podiatr Med Surg VL - 17 IS - 4 N2 - Frostbite injury to the extremities has the potential for disastrous effects. Prompt recognition and treatment are paramount. The use of Pentoxifylline to minimize tissue damage in the treatment of frostbite is a viable addition to the traditional therapy of rewarming soaks, pain management, and vesicle débridement. The most well known action of Pentoxifylline is its ability to increase RBC flexibility, allowing easier vascularization. This explains its indication for PVD, arterial disease, and intermittent claudication. As is explained previously, however, Pentoxifylline has multiple actions that will enhance tissue survival. The dosage of Pentoxifylline in controlled release tablet form is one 400 mg tablet three times a day with meals. The duration of treatment should be from two to six weeks. As this drug has many actions and therefore possibilities, more research is warranted with regards to its use not only with frostbite, but with other pathological processes. SN - 0891-8422 UR - https://www.unboundmedicine.com/medline/citation/11070801/Pentoxifylline__Adjunctive_therapy_in_the_treatment_of_pedal_frostbite_ L2 - https://medlineplus.gov/frostbite.html DB - PRIME DP - Unbound Medicine ER -